晚期胃癌转化治疗策略的研究进展

Progress of Conversion Therapy for Advanced Gastric Cancer

胃癌是最常见的消化系统肿瘤。由于其生物学行为活跃,大约50%的患者就诊时已经处于晚期,初期无法行根治治疗,目前常用的治疗方案为姑息性化疗或最佳支持性治疗,患者生存期有限。通过转化治疗有可能使部分初始不可切除或潜在可切除的晚期胃癌患者获得根治性手术切除的机会,进而延长生存时间。特别是近几年,通过转化治疗使晚期胃癌患者获得根治机会从而延长生存时间的方式越来越受到医务人员的重视。由于转化治疗方式目前尚无统一标准,本文拟就转化治疗的策略进行综述,为临床医生在转化治疗选择方案时提供一些参考。

Gastric cancer is the most common gastrointestinal cancer. Because gastric cancer cells are biologically active,about 50% of gastric cancer patients are at the advanced stage at the first visit to hospital. These patients can not be treated radically at an early stage. Palliative chemotherapy or best supportive care is the current standard treatment for advanced gastric cancer,and the survival of them is poor. It is possible to obtain radical resection in some patients with advanced gastric cancer who are initially unresectable or potentially resectable through conversion therapy,thus prolonging the survival time. In recent years,conversion therapy gets more and more attention since it provides opportunity for radical treatment for patients with advanced gastric cancer and prolongs survival time of them. However,there is no standard for conversion therapy at present. This paper reviews the strategy of conversion therapy,and provides references for clinicians in choosing treatment options.