妊娠期乳腺癌的诊疗新进展

Advances in Diagnosis and Treatment of Gestational Breast Cancer

妊娠期乳腺癌是指发生于妊娠期和(或)哺乳期的乳腺癌,包括从妊娠起始至分娩后1年内新发生的乳腺癌,是一种发病率较低的特殊类型乳腺癌。因其在发病初期容易被误诊漏诊、初诊时分期相对晚、腋窝淋巴结易发生转移、组织学分型差,预后相对较差。同时,处于妊娠期的患者治疗中需要考虑母体和胎儿对手术治疗及全身治疗的耐受性,治疗方案的选择应格外慎重。本文将结合相关文献及2019年美国国立综合癌症网络乳腺癌治疗指南对妊娠期乳腺癌的流行病学、诊断、治疗和预后等方面进行总结和探讨。

Gestational or pregnancy-associated breast cancer is defined as breast cancer that is diagnosed during pregnancy,in the first postpartum year,or any time during lactation. And it is a special type of breast cancer with a low incidence.It is prone to be misdiagnosed and miss diagnosed,be relatively late stage at the first visit to hospital,and have axillary lymph node metastasis,poor histological type and comparatively poor prognosis. Treatment options should be selected with extreme caution considering maternal and fetal tolerance to surgical treatment and systemic therapy. This review will combine relevant articles and National Comprehensive Cancer Network Breast Cancer Treatment Guidelines(2019) to summarize and investigate the epidemiology,diagnosis,treatment and prognosis of gestational breast cancer.