血清OPN、血CD4^+、CD8^+水平变化与肾癌患者临床分期的关联性分析

Correlation Analysis between Serum OPN,Blood CD4^+,CD8^+ Levels and Clinical Stage of Renal Cell Carcinoma Patients

目的研究血清骨桥蛋白(OPN)、血CD4^+、CD8^+水平变化与肾癌患者临床分期的关联性.方法选取2017年9月~2018年9月我院收治的肾癌患者180例为观察组,经病理切片证实,临床分期:Ⅰ期44例、Ⅱ期70例、Ⅲ期39例、Ⅳ期27例,另选同期健康体检者90例为对照组.均检测血清OPN、血CD4^+、CD8^+水平,对比不同受检对象间上述物质水平,分析其水平与肾癌临床分期的相关性.结果观察组血清OPN、血CD8+水平高于对照组,血CD4+水平低于对照组(P<0.05);经单因素方差分析,不同临床分期间血清OPN、血CD4+水平对比,差异有统计学意义(P<0.05);不同临床分期间血清OPN、血CD4^+水平两两对比,Ⅳ期血清OPN水平高于Ⅲ期,血CD4^+水平低于Ⅲ期,Ⅲ期血清OPN水平高于Ⅱ期,血CD4^+水平低于Ⅱ期,Ⅱ期血清OPN水平高于Ⅰ期,血CD4+水平低于Ⅰ期(P<0.05);不同临床分期间血CD8^+水平对比,差异无统计学意义(P>0.05);经Spearman分析,血清OPN水平与肾癌临床分期呈正相关(P<0.05);血CD4^+水平与肾癌临床分期呈负相关(P<0.05).结论肾癌患者血清OPN、血CD4^+、CD8^+水平变化显著,且血清OPN、血CD4+水平与临床分期关系密切,通过检测上述指标,可为临床疗效及预后评估提供数据支持.

Objective To study the relationship between serum osteopontin(OPN),blood CD4^+,CD8^+ levels and clinical stage of renal cell carcinoma patients.Methods From September 2017 to September 2018,180 patients with renal cell carcinoma in our hospital were selected as observation group.The clinical stages were confirmed by pathological section: 44 cases in stage Ⅰ,70 cases in stage Ⅱ,39 cases in stage Ⅲ,and 27 cases in stage Ⅳ.Another 90 healthy people in the same period were selected as the control group.Serum OPN,blood CD4^+,and CD8^+ levels were measured,and the levels of the above substances were compared between different subjects.The correlation between the levels and the clinical stage of renal cancer was analyzed.Results The levels of serum OPN and blood CD8^+ in the observation group were higher than those in the control group,and the blood CD4^+ level was lower than that in the control group(P<0.05).The difference of serum OPN and blood CD4^+ levels in different clinical stages was statistically significant by one-way analysis of variance.(P<0.05);Pairwise contrast,stage Ⅳ serum OPN level is higher than stage Ⅲ,blood CD4^+ level is lower than stage Ⅲ,stage Ⅲ serum OPN level was higher than stage Ⅱ,blood CD4^+ level is lower than stage Ⅱ,stage Ⅱ serum OPN The level was higher than stage I,blood CD4^+ level was lower than stage I(P<0.05);there was no significant difference in blood CD8^+ level between different clinical stages(P>0.05);Spearman analysis,serum OPN level and renal cancer clinical The stage was positively correlated(P<0.05);the blood CD4^+ level was negatively correlated with the clinical stage of renal cell carcinoma(P<0.05).Conclusion The levels of serum OPN,blood CD4^+ and CD8^+ in renal cell carcinoma patients are significantly different,and serum OPN and blood CD4^+ levels are closely related to clinical stage.By testing the above indicators,data support for clinical efficacy and prognosis evaluation can be provided.