摘要
咔唑及其衍生物在医药和光电材料领域有着广泛的应用.合成了一种稳定的含有咔唑基团的环状高价碘试剂,该试剂属于苯并碘氧杂环类化合物,在Cu(I)催化条件下可以与芳烃底物反应,得到N-芳基咔唑衍生物,反应条件温和,适用于多种富电子芳烃,并提出了一个可能的自由基反应机理.
Carbazole and its derivatives are widely used in the field of medicine and photoelectric materials.A kind of stable cyclic hypervalent iodine reagents containing carbazole group was developed,which belong to benziodoxole compounds.In the presence of Cu(I) catalyst,these reagents reacted with aromatic substrates to give N-aryl carbazole derivatives.The reaction conditions are mild and suitable for a variety of electron-rich arenes.And a radical mechanism was proposed.
作者
兰天磊
张越
刘伟
席婵娟
陈超
Lan Tianlei;Zhang Yue;Liu Wei;Xi Chanjuan;Chen Chao(Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084;College of Chemical Engineering and Materials Science,Tianjin University of Science & Technology,Tianjin 300457;College of Sciences,Tianjin University of Science & Technology,Tianjin 300457)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第8期2166-2174,共9页
Chinese Journal of Organic Chemistry
基金
国家重点研发计划(No.2016YFB0401400)
国家自然科学基金(Nos.21302139,21672120,21871158)
霍英东青年教师基金(No.151014)资助项目~~
关键词
咔唑
高价碘试剂
N-芳基化
铜催化
carbazole
hypervalent iodine reagent
N-arylation
copper-catalysis
