有机磷催化γ-甲基联烯酸酯[3+2]环化反应

Phosphine-Catalyzed [3+2] Annulations with γ-Methyl Allenoates

在有机磷催化下,γ-甲基联烯酸酯和烯基茚二酮经过[3+2]环加成反应,以中等到较好的产率、高化学选择性和非对映选择性形成一系列官能团化的螺环化合物.该反应具有操作简单、反应条件温和和底物适用性广等优点.需要指出的是,使用简单易得的PPh3作为催化剂,就能实现完全的α-区域选择性加成的环化产物.

The phosphine-catalyzed[3+2] annulation of γ-methyl allenoates with 2-arylidene-1H-indene-1,3(2H)-diones is reported.In the reaction,a series of highly functionalized spiro[4.4]dec-6-ene skeletons were obtained in moderate to good yields and high diastereoselectivities.It should be noted that the perfect α-regioselective annulation adducts were obtained with simple PPh3 catalyst.