80例阿替普酶治疗急性脑梗死疗效分析

Treatment of Acute Cerebral Infarction with Altipase in 80 Cases

目的:观察阿替普酶对急性脑梗死的临床效果。方法:选80例急性脑梗死患者为受试者,阿替普酶起始剂量控制在9mg/kg,在1分钟内开始10%阿替普酶静脉推注,其余90%静脉泵入,1小时内泵入完毕。在溶栓前、溶栓后6小时、24小时及1周评估NIHSS评分。结果:治疗6小时、24小时、1周后的NIHSS评分均低于治疗前NIHSS评分,差异有统计学意义(P<0.05)。结论:应用阿替普酶静脉溶栓治疗急性脑梗死,症状改善明显,超范围使用仍有临床疗效,且不良反应较小,具有临床应用价值。

Objective:To observe the clinical effect of alepinase on acute cerebral infarction.Methods:80 patients with acute cerebral infarction were selected for the study.The initial dose of aleptase was controlled at 9 mg/kg,10 % of aleptase 1 min was injected into the vein,the remaining 90 % was pumped into the vein,and the pump was completed within 1 hour.To observe the effect of clinical treatment.Results:The NIHSS score for 6 hours,24 hours,and 1 week was lower than the NIHSS score before treatment,and the difference was statistically significant(P<0.05).Conclusion:the treatment of acute cerebral infarction with atyptase intravenous thrombolytic therapy shows obvious symptom improvement,and the clinical effect of overuse is still small.