氧化石墨烯修饰壳聚糖药物载体的构建

Construction of Graphene Oxide Modified Chitosan Drug Carrier

采用化学交联法制备了氧化石墨烯/壳聚糖(GO/CS)药物载体,并进行红外光谱、扫描电镜、孔隙率、吸水率、力学性能测试,研究了引入GO以后对CS理化性能及载药性能的影响。结果表明,GO和CS发生了有机结合,制备的GO/CS药物载体具有均匀的孔洞结构。相比于CS,GO/CS的孔径和孔隙率有所提升,引入GO之后该材料具有较好的保湿性能,尤其力学性能得到显著提升。此外,采用阿仑膦酸钠对材料的载药性及生物相容性进行了研究,结果表明,引入GO后材料的载药性能得到提高,对比单纯的CS,GO/CS的载药率提升了6.3%;MC3T3细胞实验结果表明,细胞能很好地在材料上黏附生长,在细胞接种7d后,细胞能与材料很好地结合。

The graphene oxide/chitosan(GO/CS)drug carrier was prepared by chemical cross-linking method,the physical and chemical properties,mechanical properties and drug loading performance of CS after introduction of GO were studied.The results show that strong interaction between GO and CS is displayed by FT-IR and the GO/CS drug carrier has an uniform pore structure by SEM.Compared with CS,the GO/CS pore size and porosity increase,and the moisturizing properties are good after the introduction of GO,especially the mechanical properties are significantly improved.In addition,alendronate sodium drugs were commonly used for the treatment of osteoporosis to further study the drug-loading properties and biocompatibility of the GO/CS composite materials.The results show that the drug-loading performance of the materials is improved after the introduction of GO.Compared with CS,the drug loading rate of GO/CS is increased by 6.3%.In addition,evaluated the biocompatibility of the materials.The MC3T3 cell experiment results show that the cells are adhered well to the growth of the materials,and the cells could be well combined with the material after 7 d of cell inoculation.