连接蛋白43基础研究及其分子成像的研究进展

Progress in basic research and molecular imaging of connexin 43

连接蛋白(Cx)是哺乳动物体内广泛存在的一种膜蛋白,在哺乳动物体内其分子质量介于26~56ku。连接蛋白43(connexin 43,Cx43)是哺乳动物体内表达最为广泛的连接蛋白,其在心血管疾病以及肿瘤的发生、发展中扮演着重要的角色。近年来,随着分子影像的快速发展,将Cx43作为分子成像靶点,可能成为心血管疾病以及肿瘤诊疗的一种全新手段。

Connexin(Cx)is a membrane protein widely presents in mammals.Its molecular weight ranges from 26 ku to 56 ku in mammals.connexin 43(Cx43)is the most widely expressed connexin in mammals and plays an important role in the development and progression of cardiovascular diseases and tumors.In recent years,with the rapid development of molecular imaging,Cx43 as a molecular imaging target may become a new means of cardiovascular disease and tumor diagnosis and treatment.