血小板活化与炎症性肠病

Platelet activation in inflammatory bowel disease

血小板的种系发生提示其在免疫炎症中起重要作用,近年来发现血小板活化与炎症性肠病的活动性密切相关,活化的血小板可以释放炎症介质,表达介导炎症反应的表面分子,可与白细胞和内皮细胞发生相互作用,这为抗血小板药物治疗炎症性肠病提供了理论依据。

Platelet lineage suggests that it plays a crucial role in immune responses.In recent years,many studies have found that platelet activation is closely related to the activity of infl ammatory bowel disease.Activated platelets can release inflammatory mediators,and express surface molecules that mediate inflammation,interact with leukocytes and vascular endothelial cells.It provides a theoretical basis for antiplatelet drugs to treat the infl ammatory bowel disease.