连续性肾脏替代治疗与间歇性血液透析治疗重症急性肾衰的比较研究

Comparative study of continuous renal replacement therapy and intermittent hemodialysis in severe acute renal failure

目的:探讨对重症急性肾衰患者采取两种治疗方法的临床疗效。方法:选取我院接收的66例重症急性肾功能衰竭患者作为研究对象,根据随机数字表法分为对照组(n=33,采取间歇性血液透析治疗)和观察组(n=33,采取连续性肾脏替代治疗),比较两组肾功相关指标水平变化情况、炎性因子相关指标水平变化情况、临床有效率以及住院时间和肾功能恢复时间。结果:治疗后,观察组患者Scr、BUN及Ccr等优于治疗前,与对照组相比差异有统计学意义(P<0.05);治疗后,观察组炎性因子相关指标水平优于治疗前,与对照组相比差异有统计学意义(P<0.05);观察组临床有效率84.8%较对照组的69.7%更高,两组相比差异有统计学意义(P<0.05);观察组患者住院时间及肾功能恢复时间均较对照组更短,两组相比差异有统计学意义(P<0.05);观察组治疗期间心血管事件发生率30.3%低于对照组的60.6%,两组相比差异有统计学意义(P<0.05)。结论:重症急性肾衰患者采取急性肾脏替代治疗,临床疗效显著,安全性良好,值得临床广泛推广。

Objective: To discuss the clinical efficacy of two therapies in severe acute renal failure. Methods: 66 severe acute renal failure patients treated in our hospital were selected and randomly assigned to control group(n=33)and observation group(n=33). The control group was treated withintermittent hemodialysis(IHD);the observation group was treated with continuous renal replacement therapy(CRRT). The therapeutic effect was probed. Results: After treatment, the values of Scr(serum creatinine),BUN(blood urea nitrogen)and Ccr(endogenous creatinineclearance rate)in the observation group were better than that of control group(P<0.05);after treatment, inflammatory indicators in the observation group were lower than that of control group(P<0.05);the effective rate in the observation group was higher than that of control group(P<0.05);the hospitalization time and renal function recovery time in the observation group was shorter than that of control group(P<0.05). Conclusions: CRRT has favorable effects and higher safety. It shall be widely applied in clinical practice.