低分子肝素与小剂量阿司匹林联合治疗自身免疫型复发性流产的临床效果评估

Clinical evaluation of combined low molecular weight heparin and low dose aspirin in the treatment of autoimmune recurrent abortion

目的:探索低分子肝素与小剂量阿司匹林联合治疗自身免疫型复发性流产的临床效果。方法:选取2017-01-22~2018-06-22我院自身免疫型复发性流产100例患者(实施奇偶数法分组模式),对照组的50例患者进行叶酸治疗,观察组的50例患者进行低分子肝素联合小剂量阿司匹林治疗。结果:观察组足月分娩率90.00%、血浆叶酸(18.69±2.44)ug/L、红细胞叶酸(758.95±25.86)ug/L、血浆HCY(5.19±1.41)umol/L、t-PA(0.15±0.06)AU/mL、APTT(32.86±3.22)s、纤维蛋白原(2.68±0.68)g/L、PAI-I(0.28±0.12)U/mL、E2(556.86±28.62)ng/L、P(31.75±3.69)ug/L、HCG(6854.52±18.95)U/L均优于对照组(P<0.05)。结论:对自身免疫型复发性流产患者实施低分子肝素联合小剂量阿司匹林治疗效果显著。

Objective:To explore the clinical effect of combining low-molecular weight heparin and low-dose aspirin in the treatment of autoimmune recurrent abortion.Methods: One hundred patients with auto-immune recurrent abortion in our hospital were selected on January 22, 2017 solstice, June 22, 2018. They were divided into the control group and the observation group according to the even number method. 50 patients in the control group were treated with folic acid, and 50 patients in the observation group were treated with low-molecular weight heparin combined with low-dose aspirin.Results:In the observation group, the delivery rate was 90.00%, plasma folate (18.69±2.44) mug /L, erythrocyte folate (758.95±25.86) mug /L, plasma HCY (5.19±1.41) mumol /L, t-pa (0.15±0.06) AU/mL, APTT (32.86±3.22) s, fibrinogen (2.68±0.68) g/L, pai-i (0.28± 0.12) U/mL, E 2 (556.86±28.62) ng/L, and P (31.75±3.69) muoG /L and HCG (6854.52±18.95) U/L were better than the control group (P<0.05). Conclusion:The combination of low molecular weight heparin and low dose aspirin is effective in the treatment of patients with autoimmune recurrent abortion.