静电纺丝纤维作为牙周药物传递系统的研究进展

Progress in electrospun fibres as periodontal drug delivery systems

静电纺丝技术是利用聚合物溶液或熔体在高压电场作用下形成喷射流拉伸从而形成纳米/微米级直径纤维的技术,其制备的生物支架材料具有生物相容性好、比表面积大、孔隙率高、易改性和成本低等优点,在再生医学、组织工程、创伤敷料、医用纺织材料和药物传递系统等领域研究广泛,作为牙周药物传递系统也具有良好的应用前景。本文就静电纺丝技术和静电纺丝纤维作为牙周药物传递系统的载药方式、载药类型、作用方式、应用形式及前景展望等方面进行综述。

Electrospun synthesizes nanometer or micrometer fibers used by polymer solutions or melts under high-voltage electric fields. Electrospun fibers have the advantages of good biocompatibility, large specific surface area, high porosity, easy modification and low cost, they are widely used in regenerative medicine, tissue engineering, wound dressing, medical textile materials and drug delivery systems. Electrospun fibres also have good application prospects as periodontal drug delivery systems. Progress in electrospun fibres as periodontal drug delivery systems is summarized.