尿酸排泄分数与肾功能关系的研究

Relationship between urinary fractional excretion of uric acid and renal function in patients with chronic kidney disease

目的探讨慢性肾脏病患者中,尿酸排泄分数与肾功能的关系。方法搜集检测24 h尿相关指标的慢性肾脏病患者245例,根据尿酸排泄分数(fraction excretion of uric acid, FEUA)的四分位数间距分为4组(FEUA 1~4),分析尿酸排泄分数与肾功能的关系。运用相关性分析,研究FEUA与预估肾小球滤过率(eGFR)、24 h尿蛋白的关系。采用Logistic回归方法分析各临床指标与肾功能的关系。结果随着FEUA的逐渐升高,eGFR逐渐降低;而且FEUA与eGFR负相关( r =-0.591 , P <0.000 1);FEUA与24 h尿蛋白正相关( r =0.408, P <0.000 1)。Logistic回归表明,FEUA与肾功能相关(OR=1.085,95%CI=1.008~1.167, P =0.035)。结论在慢性肾脏病患者,FEUA是肾功能的危险因素;而且FEUA水平越高,肾功能越差。

Objective To investigate the relationship between urinary fractional excretion of uric acid (FEUA) and renal function in patients with chronic kidney disease (CKD).Methods Two hundred and forty-five CKD patients were enrolled in the study and 24-h-urine parameters were collected.According to the quartile of FEUA,patients were classified into FEUA 1-4 groups.The relationship between EFUA and estimated glomerular filtration rate (eGFR),and 24 h urinary protein were analyzed with Spearman correlation analysis;and the association of renal function with clinical parameters was analyzed with multiple Logistic regression analysis.Results The FEUA level was negatively correlated with eGFR ( r =-0.591,P <0.000 1) and positively correlated with 24 h urinary protein ( r =0.408,P <0.000 1) in CKD patients.The multiple Logistic regression analysis indicated that FEUA was an independent risk factor for decreased renal function (OR=1.085,95%CI=1.008-1.167,P =0.035).Conclusion Higher urinary fractional excretion of uric acid is associated with a worse renal function in patients with chronic kidney disease.