三种消毒剂胃镜消毒效果的Meta分析

Comparison of disinfection effects of three disinfectants on gastroscope: a meta analysis

目的评估戊二醛、邻苯二甲醛和过氧乙酸对胃镜的消毒效果。方法计算机检索Medline ( PubMed) Cochrane Library、web of science xEmbase s 中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP),收集所有戊二醛、邻苯二甲醛及过氧乙酸对胃镜消毒效果的随机对照试验,按照纳入与排除标准筛选文献并提取资料,采用RevMan 5. 3. 4.0软件进行Meta分析。结果最终纳入18篇文献,Meta分析结果显示,戊二醛的消毒效果和邻苯二甲醛差异有统计学意义(0R=2. 02,95%CI:1.88~2. 17,Pv0.000 01),过氧乙酸的消毒效果和戊二醛差异有统计学意义(0R = 2. 79,95%CI:1.52~5. 11 ,P= 0. 000 9),邻苯二甲醛的消毒效果和过氧乙酸差异无统计学意义(0R= 1. 30,95%CI:0. 62~2. 73,P=0.49) o结论邻苯二甲醛和过氧乙酸对胃镜的消毒效果相近,两者均明显优于戊二醛。但由于过氧乙酸相比邻苯二甲醛价格低廉且无腐蚀性,因此胃镜消毒剂选择过氧乙酸优于戊二醛和邻苯二甲醛。

Objective To evaluate the disinfect effects of glutaraldehyde, ortho-phthalaldehyde (OPA) and peracetic acid on gastroscopy disinfection. Methods Relevant literature from PubMed, Cochrane Library, web of science, Embase, CNKI, CBM, VIP were retrieved to collect the randomized controlled trials on disinfection by glutaraldehyde, OPA and peracetic acid on gastroscope. Literature was selected according to the inclusion and exclusion criteria. The RevMan 5. 3. 4. 0 statistic software was used to extract data and a meta-analysis was performed. Results A total of 18 RCT were included. There were significant differences in the disinfect effects between the OPA group and the glutaraldehyde group ( OR = 2. 02, 95%CI: 1. 88-1. 27, P<0.000 01 ), and between the peracetic acid group and the glutaraldehyde group ( OR = 2. 79, 95% CI: 1. 52-5. 11, P = 0. 000 9 ). There were no significant differences in the disinfection effect between the OPA group and peracetic acid group ( OR = 1. 30,95%CI:0. 62-2. 73, P = 0. 49). Conclusion The disinfect effects of OPA and peracetic acid are similar, which are superior to glutaraldehyde. Compared with OPA and glutaraldehyde, peracetic acid is a better choice considering its good disinfect effect and low cost.