摘要
淋病是由淋病奈瑟球菌(淋球菌)感染人体生殖道所致的性传播疾病。由于疫情攀升和淋球菌耐药问题的发展,淋病已成为全球性公共卫生问题。近年来,基于核酸检测的淋球菌分型技术日渐成熟,已逐渐成为淋病分子流行病学研究中的重要工具。此文综述了淋病分子流行病学研究的最新进展,分别阐述基于DNA凝胶电泳和序列测序的常见分型方法,以及该类方法在淋球菌耐药性检测和传播网络等方面的应用,从而促进淋病治疗用药方案和防控措施的探索。
Gonorrhoea is a sexually transmitted disease caused by Neisseria gonorrhoeae infection of the human reproductive tract.Along with the rapid increase of both incidence and drug resistance,gonorrhoea has been one of the global public health problems.With the development of nucleic acid detection,the gonococcal typing technology has gradually become an important research tool in the molecular epidemiology of gonorrhea.This review summarizes recent advances in molecular epidemiology of gonorrhea,including the common typing methods based on DNA gel electrophoresis and sequence sequencing,and the application of these methods in the resistance detection and sexual network,so as to promote the further exploration of treatment therapy and control protocol for gonorrhea.
作者
杨韵青
朱慧兰
罗权
汤少开
何婉苹
梁容娇
钟雪莲
彭嘉俊
王建琴
陈祥生
Yang Yunqing;Zhu Huilan;Luo Quan;Tang Shaokai;He Wanping;Liang Rongjiao;Zhong Xuelian;PengJiajun;Wang Jianqin;Chen Xiangsheng(Guangzhou Institute of Dermatology China,Guangzhou 510095,China;Institute of Dermatology,Chinese Academy of Medical Sciences/National Center for STD Control,China CDC,Nanjing 210042,China)
出处
《国际流行病学传染病学杂志》
CAS
2019年第4期322-326,共5页
International Journal of Epidemiology and Infectious Disease
基金
广州市卫生科技计划重大项目(20181A031003).
关键词
奈瑟球菌
淋病
分子流行病学
分型
传播网络
Neisseria gonorrhoeae
Molecular epidemiology
Typing
Sexual network
