儿童乳糜泻筛查与预后研究进展

Study progress of screening and prognosis of celiac disease in children

乳糜泻是指遗传易感个体摄入含麸质蛋白及其相关醇溶蛋白后所引发免疫介导的全身系统疾病,典型患者可出现吸收不良等症状,可伴发多种肠外表现,乳糜泻是可筛查、可治疗的疾病,但延迟诊断,可出现多种显著影响儿童生长发育的并发症,如果及时诊断并给予严格免麸质饮食,可明显改善患儿预后。现总结近年来国内外关于儿童乳糜泻的相关文献,就儿童乳糜泻筛查、预后等方面作一综述。

Celiac disease is immune-mediated systemic disorder that occurs in genetically predisposed individuals after ingestion of gluten and related prolamines.Patients may suffer from intestinal symptoms such as chronic diarrhea, accompanied by multiple extraintestinal manifestations.Celiac disease is a screenable and treatable disease.If celiac disease in children are delayed, some complications may significantly affect children′s growth and development.The prognosis of the children can be improved if the diagnosis is made in time and the gluten-free diet is given strictly.Now, the relevant literature on screening and prognosis of children′s celiac disease in recent years was summarized.