手术联合光动力治疗难治性跖疣的临床效果

Clinical effect of surgical removal combined with 5-aminolevulinic acid photodynamic therapy for plantar warts

目的探讨手术联合光动力疗法治疗难治性跖疣的临床疗效。方法2017年7月至2018年6月,苏州市第五人民医院皮肤科收集16例跖疣患者,其中男12例,女4例,年龄10~42岁,病程4~15个月,疣体合计47处。通过手术削除、双极电凝烧灼的方法将疣体去除后,用氨基酮戊酸光动力治疗,间隔7~10 d治疗1次,一般治疗3~4次。结果11例患者经1次手术加3次光动力治疗;5例患者2次手术加4次光动力治疗,效果均满意。随访6个月,16例患者47处疣体全部消失,疣体清除率100%,皮纹存在。除术后局部出现轻度红肿、疼痛、烧灼感外,未发生感染、溃疡、明显瘢痕等不良反应。结论手术联合氨基酮戊酸光动力疗法是治疗跖疣的好方法。

Objective To observe the clinical efficacy of surgical operation combined with photodynamic therapy for plantar warts. Methods From July 2017 to June 2018, 16 patients with plantar warts were enrolled in the Department of Dermatology, the Fifth People's Hospital of Suzhou City. The enrolled patients aged 10 to 42 years, including 12 males and 4 females, with a course of 4 to 15 month, and a total of 47 plantar warts. The plantar warts was removed by surgical operation and bipolar coagulation, followed by the photodynamic treatment with 5-aminolevulinic acid for 3 to 4 times with an interval of 7-10 days. Results Eleven patients showed complete clearance after operation and three times photodynamic treatments, and the other 5 patients underwent 2 operations and four times photodynamic treatments. 47 plantar warts in 16 patients were disappeared completely during 6-month post-treatment follow up. The plantar warts clearance rate was 100%, and the skin texture still presented. In addition to local mild erythematous, pain and burning sensation presented after surgery, but no adverse reactions such as infection, ulcers and obvious scars occurred. Conclusions Surgery combined with 5-aminolevulinic acid photodynamic therapy is a favorable treatment for plantar warts.