肿瘤相关脂肪细胞促进乳腺癌侵袭及转移机制的研究进展

Role of cancer-associated adipocytes in promoting invasion and metastasis of breast cancer

脂肪细胞是多种组织的主要基质细胞之一,是肿瘤微环境中的重要组成成分。肿瘤相关脂肪细胞存在于肿瘤细胞周围,可分泌各种脂肪因子和细胞因子,通过介导局部和全身作用影响肿瘤细胞的表型和功能,促进乳腺癌侵袭、转移。本文就肿瘤相关脂肪细胞分泌的趋化因子CC基序配体2、5以及炎性因子白细胞介素-6、肿瘤坏死因子-α在乳腺癌侵袭、转移中作用的研究进展作一综述。

Adipocyte is one of the major stromal cells in many tissues and is considered to be an important component in the tumor microenvironment. Cancer-associated adipocytes are present around tumor cells and secrete various adipokines and cytokines to promote the invasion and metastasis of breast cancer by mediating local and systemic effects on the phenotype and function of tumor cells. This paper reviews the research progress of the roles of inflammatory factors secreted by cancer-associated adipocytes, such as CCL5, CCL2, interleukin-6, and tumor necrosis factor-α in the invasion and metastasis of breast cancer.