利培酮对首发精神分裂症患者脑电图的影响分析

Effect of risperidone on electroencephalogram in patients with first-episode schizophrenia

目的探讨分析利培酮对首发精神分裂症患者脑电图的影响。方法回顾性分析我院2016年2月~2017年2月收治的首发精神分裂症患者200例,患者在服药前,及服药1月后,服药2月后均进行脑电图测试,观测并记录患者脑电图变化情况并分析。结果患者服用利培酮1、2月后脑电图异常率为40.5%、46.5%均明显高于治疗前的11.0%(P<0.05);并且治疗1、2月后脑电图以轻中度异常率为主(P<0.05)。治疗2个月后脑电图中度异常率为22.0%明显高于治疗1个月后的10.0%(P<0.05)。Logistic回归分析显示,年龄> 50岁、BMI <18.5或≥30和糖尿病是导致精神分裂症患者脑电图发生异常的独立危险因素。结论服用利培酮的首发精神分裂症患者有约40%异常脑电图发病率,但一般为轻中度异常,与服药时间无关。需注意控制患者体重和血糖,并对老年患者定期复查脑电图,以减少不良反应发生。

Objective To explore the effect of risperidone on the electroencephalogram in patients with firstepisode schizophrenia. Methods A retrospective analysis of 200 cases of first-episode schizophrenics admitted to our hospital in February 2016-February 2017 was conducted. EEG tests were performed before and after taking the drug. EEG changes were recorded and abnormal EEG was analyzed. Results After taking risperidone 1 and 2 months,the abnormal rate of EEG was 40.5% and 46.5%,which were significantly higher than 11% before treatment(P<0.05);And after 1 and 2 months,the EEG was mainly mild to moderate(P<0.05). After 2 months,the moderate abnormal rate of EEG was 22%,which was significantly higher than that of 10% months after 1 months’ treatment(P<0.05). Logistic regression analysis showed that age> 50 years,BMI <18.5 or ≥ 30,and diabetes mellitus are independent risk factors for EEG abnormalities in schizophrenic patients. Conclusions First-episode schizophrenia patients taking risperidone have about 40% abnormal EEG rates,but are generally mild-moderately abnormal and are not associated with medication time. It is necessary to control the body weight and blood glucose of the patients,and to review the EEG of the elderly patients regularly to reduce the occurrence of adverse reactions.