喹硫平联合拉莫三嗪对躁狂发作患者的疗效及安全性

The efficacy and safety of quetiapine combined with lamotrigine in mania patients

目的观察喹硫平联合拉莫三嗪治疗躁狂发作患者的疗效及安全性。方法将2015年11月~2018年1月60例在我院接受治疗的躁狂发作患者随机原则将分为观察组(30例)与对照组(30例),分别给予喹硫平联合拉莫三嗪治疗与单纯喹硫平治疗,对两组患者治疗前后躁狂评分(BRMS)、临床效果以及不良反应发生情况进行综合评价。结果治疗后观察组患者的BRMS评分低于对照组(P<0.05);观察组患者治疗总有效率达到93.3%,高于对照组的70.0%(P<0.05);观察组不良反应发生率与对照组无明显差异(P>0.05);观察组的喹硫平用量低于对照组(P<0.05)。结论喹硫平联合拉莫三嗪能够改善躁狂发作患者的症状,减少喹硫平用量,不增加不良反应。

Objective To observe the efficacy and safety of quetiapine combined with lamotrigine in mania patients. Methods 60 patients with mania treated in our hospital from November 2015 to January 2018 were included and randomly divided into observation group(30 cases)and control group(30 cases). The patients in observation group were treated with quetiapine combined with lamotrigine,while control group were quetiapine alone. The mania score(BRMS),clinical efficacy and adverse reactions of the two groups were evaluated before and after treatment. Results After treatment,the BRMS score in the observation group was significantly lower than that in the control group(P<0.05);the total effective rate of in the observation group was 93.3%,which was higher than that(70.0%)in the control group(P<0.05);There were no difference on the adverse reactions between two groups(P>0.05). The dosage of quetiapine in the observation group was lower than that in the control group(P<0.05). Conclusion Quetiapine combined with lamotrigine can improve the manic state of patients without increasing adverse reactions.