女性抑郁发作患者甲状腺功能分析

Analysis of thyroid function in female depressive patients

目的研究女性抑郁发作患者治疗前后血清甲状腺激素水平变化及相关性分析。方法随机选取在我院住院、符合ICD-10抑郁发作诊断标准的女性患者70例入观察组,招募与观察组相匹配的70例健康志愿者入对照组。观察组测定基线与艾司西酞普兰治疗4周末血清甲状腺激素水平,同时给予17项汉密尔顿抑郁量表评分(HAMD-17)和14项汉密尔顿焦虑量表(HAMA-14),对照组测定基线甲状腺激素水平。比较两组基线甲状腺激素水平、观察组治疗前后甲状腺激素水平变化及相关性。结果基线期观察组血清T3、T4、FT3、FT4水平均低于对照组(P均<0.01,t=1.99、1.41、2.47、3.34);观察组治疗4周末较基线期FT4水平有所升高(P<0.05,t=3.687)。观察组FT3、FT4水平与HAMA-17、HAMD-14评分总分均呈显著正相关(P<0.01),TSH水平与病程呈正相关(P<0.05)。结论女性抑郁发作患者甲状腺功能发生改变,可能与病程、焦虑和抑郁的严重程度相关。

Objective To study the changes and correlation of serum thyroid hormone levels in patients with depressive episodes before and after treatment. Methods A total of 70 female patients who were hospitalized in our hospital and met the diagnostic criteria for ICD-10 depressive episodes were enrolled in the observation group.70 healthy volunteers matched with the observation group were enrolled in the control group. The observation group measured serum thyroid hormone levels at baseline and escitalopram for 4 weeks,and administered 17 Hamilton Depression Rating Scales(HAMD-17)and 14 Hamilton Anxiety Scales(HAMA-14). Hormone levels. The baseline thyroid hormone levels were compared between the two groups,and the changes and correlations of thyroid hormone levels before and after treatment in the observation group. Results The serum levels of T3,T4,FT3,and FT4 in the baseline observation group were lower than those in the control group(P<0.01,t=1.99,1.41,2.47,3.34). The observation group was increased at the 4 th week compared with the baseline FT4 level. High(P<0.05,t=3.687). The levels of FT3 and FT4 in the observation group were significantly positively correlated with the total scores of HAMA-17 and HAMD-14(P<0.01),and the levels of TSH were positively correlated with the course of disease(P<0.05). Conclusion Changes in thyroid function in women with depressive episodes may be related to the severity of the disease,anxiety and depression.