绝经后女性骨密度与冠状动脉钙化的相关性研究

Correlation between bone mineral density and coronary artery calcification in postmenopausal women

目的评估绝经后妇女骨密度( bone mineral density,BMD)与冠状动脉钙化( coronary calcification,CAC)之间的相关性。方法本研究纳入120 名年龄超过55 岁的绝经后妇女作为研究对象。所有对象均收集一般临床资料;同时检测三酰甘油( TG)、低密度脂蛋白胆固醇( LDL-C)和高密度脂蛋白胆固醇( HDL-C)水平、空腹血糖( FBG)、血清钙和血清磷。髋部和腰椎( L1~ 4) BMD 使用双能X 线骨密度仪检测。CAC 采用高清计算机断层扫描技术进行测量。结果年龄与左股骨颈及腰椎L1~ 4的骨密度呈显著负相关(均P<0. 05)。CAC 的钙化积分、体积积分和质量积分与年龄呈正相关。66%的受试者中发现有CAC。各种CAC 评分(钙化、体积、质量积分)和所有身体扫描部位( L1~ 4、股骨颈)的BMD 之间没有显著的相关性( P>0. 05)。此外,在多元线性回归分析中,CAC 评分与BMD 之间的关系不存在统计学意义( P>0. 05)。结论年龄是高清计算机断层扫描技术检测到的BMD 降低和CAC 发展的重要因素。

Objective The present study was designed to evaluate the relationship between bone mineral density( BMD) and coronary artery calcification( CAC) in postmenopausal women. Methods Participants included 120 postmenopausal women older than 55 years. Clinical data of each participant was collected. Serum total glyceride( TG),low-density lipoprotein cholesterol( LDL-C),high-density lipoprotein cholesterol( HDL-C),fasting blood glucose( FBG),calcium,and phosphate were measured.BMD of the hip and lumbar vertebrae 1-4 was detected using dual energy X-ray absorptiometry. CAC was measured with highdefinition computerized tomography. Results There was a significant negative correlation between age and BMD of the left femoral neck and lumbar vertebrae 1-4( P<0. 05). For CAC,there was a moderately positive correlation between age and volume and mass scores. CAC was present in 66% of participants. There was no significant correlation between all kinds of CAC scores including calcification and volume and mass scores,and BMD of all scanned body parts including lumbar spine 1-4 and femoral neck( P> 0. 05). Furthermore,multiple linear regression analysis showed that the relationship between CAC scores and BMD remained no statistically significant( P>0. 05). Conclusion Age is an important factor for decrease of BMD and development of CAC detected by HDCT.