皮肤真菌感染与银屑病的相关性

Correlation between psoriasis and fungal infection

随着近年来银屑病的发病率逐步增加,关于银屑病病因的研究更加深入。除了遗传、免疫和环境等相关因素,微生物与银屑病的关系也备受关注。关于真菌感染与银屑病的相关性研究始于19世纪,认为糠秕马拉色菌可能是银屑病的致病因子,与银屑病的发生发展密切相关。随后也有研究指出白念珠菌通过超抗原等作用诱发或加重银屑病。但银屑病患者依据自身IL-17增高的特点可以起到一定抵抗微生物感染的作用,因此真菌感染与银屑病的关系暂无定论。随着近年来关于两者之间关系的研究逐渐增多,真菌感染仍是银屑病患者不可忽视的诱发或加重因素之一。明确真菌感染在银屑病患者体内的作用有助于更好地研究银屑病的发病机制以及改善预后。

With the increasing incidence of psoriasis in recent years,research on the etiology of psoriasis has become deepgoing.The study on the correlation between fungal infection and psoriasis began in the 19 th century,and it was believed that Malassezia infection might be the pathogenesis of psoriasis,and the fungus was closely related to the occurrence and development of psoriasis.Some studies indicated that Candida albicans induced or aggravated psoriasis through superantigen.However,relying on the characteristics of increasing IL-17,psoriasis patients can resist microbial infection to a certain extent.The relationship between fungal infection and psoriasis is not conclusive yet.With the deepening research,fungal infection is still regarded as one of the factors that can not be ignored in inducing or aggravating psoriasis.