孢子丝菌复合体分子分型研究进展

Overview of genotyping studies for Sporothrix complex

孢子丝菌复合体属于双相真菌,全球分布,可引起人类及动物的慢性深部感染。不同地域的菌株在致病力、传播途径及药物敏感性等方面均存在差异。孢子丝菌病作为一种人兽共患病,其发病率逐年上升,出现多次暴发流行。分子分型不仅是明确感染源和传播途径、预防和控制疾病流行的有力手段,同时有助于了解孢子丝菌基因型与表型的相关性,在研究其致病机制以及临床诊治过程中都具有十分重要的意义。本文对孢子丝菌的分子分型方法的研究进行综述。

Sporothrix complex is a dimorphic fungi with worldwide distribution,causing chronic deep infections in humans and animals.There are differences in virulence,transmission route and drug sensitivity among strains from different regions.As a zoonotic disease,the incidence of sporotrichosis increased year by year,and outbreaks of the disease appeared on many occasions.Molecular typing is not only a powerful method of identifying the source of infection and the route of transmission,but also preventing and controlling the epidemic.It is also helpful to understand the correlation between the genotype and phenotype of Sporothrix,and is of great significance in studying pathogenic mechanism and clinical diagnosis and treatment of the disease.In this paper,the genotyping studies for Sporothrix complex were reviewed.