摘要
脑源性神经营养因子(BDNF)是神经营养因子家族的成员之一,是一种非常重要的神经营养因子,可促进神经元生长、分化与存活,影响突触的生长和可塑性。BDNF通过控制摄食、增加饱腹感、改善胰岛素分泌、增加IS、影响机体能量代谢等在糖尿病中发挥重要作用,且与糖尿病并发症神经病变相关,本文对BDNF在糖尿病及并发症中作用的研究进展进行综述。
Brain-derived neurotrophic factor(BDNF)is a member of the neurotrophic factor family. It is a very important neurotrophic factor that promotes the growth,differentiation and survival of neurons and affects the growth and plasticity of synapses. BDNF can ameliorate diabetes by controlling feeding and increasing satiety,improving insulin secretion,increasing insulin sensitivity,and affecting energy metabolism in the body,and is associated with neuropathy of diabetic complications,This article reviews these aspects.
作者
李小华
冷锦红
LI Xiaohua;LENG Jinhong(Department of Endocrinology, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2019年第8期629-631,共3页
Chinese Journal of Diabetes
基金
辽宁省自然科学基金计划重点项目（20180530030）
沈阳市科技计划项目（18-013-0-09）
关键词
脑源性神经营养因子
糖尿病
能量代谢
胰岛素:神经病变
Brain-derived neurotrophic factor
Diabetes mellitus
Energy metabolism
Insulin
Neuropathy
