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survivin和MCM7在甲状腺乳头状癌组织中的表达及其与患者临床特征的关系 被引量:3

Expression of survivin and MCM7 in papillary thyroid carcinoma and their relationship with the clinical characteristics
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摘要 目的探讨存活蛋白(survivin)和微小染色体维持蛋白7(MCM7)在甲状腺乳头状癌组织中的表达情况及其与患者临床特征的关系。方法收集50例甲状腺乳头状癌患者的甲状腺乳头状癌组织标本、35例甲状腺腺瘤患者的甲状腺腺瘤组织标本和35例结节性甲状腺肿患者的结节性甲状腺肿组织标本。采用免疫组织化学染色法检测survivin和MCM7在3种甲状腺病变组织中的表达情况,分析survivin、MCM7在甲状腺乳头状癌组织中表达的相关性及其与甲状腺乳头状癌患者临床特征的关系。结果甲状腺乳头状癌组织中survivin和MCM7的阳性表达率均高于甲状腺腺瘤组织和结节性甲状腺肿组织(P﹤0.05)。不同性别、年龄、肿瘤直径、TNM分期、包膜是否完整、淋巴结转移情况甲状腺乳头状癌患者甲状腺乳头状癌组织中survivin的表达情况比较,差异均无统计学意义(P﹥0.05)。不同性别、年龄、包膜是否完整甲状腺乳头状癌患者甲状腺乳头状癌组织中MCM7的表达情况比较,差异均无统计学意义(P﹥0.05)。肿瘤直径﹥2cm、TNM分期为Ⅲ~Ⅳ期、有淋巴结转移甲状腺乳头状癌患者甲状腺乳头状癌组织中MCM7的阳性表达率均高于肿瘤直径≤2cm、TNM分期为Ⅰ~Ⅱ期、无淋巴转移的患者(P﹤0.05)。Pearson相关性分析结果显示,survivin和MCM7在甲状腺乳头状癌组织中的表达呈正相关(r=0.612,P﹤0.01)。结论甲状腺乳头状癌组织中survivin和MCM7的阳性表达率均较高,二者的表达呈正相关,且MCM7的表达可能与甲状腺乳头状癌患者的肿瘤直径、TNM分期和淋巴结转移情况有关,为临床鉴别诊断甲状腺乳头状癌提供依据。 Objective To investigate the expression of survivin and minichromosome maintenance protein 7(MCM7)in papillary thyroid carcinoma and the relationship with the clinical characteristics.Method Papillary thyroid carcinoma tissue samples from 50 patients with papillary thyroid carcinoma,thyroid adenoma tissue samples from 35 patients with thyroid adenoma and nodular goiter tissue samples from 35 patients with nodular goiter were collected.The expressions of survivin and MCM7 in the three kinds of thyroid pathological tissues were detected by immunohistochemical staining,and the correlation between the expression of survivin and MCM7 in papillary thyroid carcinoma tissues was analyzed,besides,the relationship between the expression of survivin and MCM7 and clinical characteristics of papillary thyroid carcinoma patients was analyzed.Result The positive expression rates of survivin and MCM7 in papillary thyroid carcinoma tissues were higher than those in thyroid adenoma and nodular goiter tissues(P<0.05).There was no significant difference regarding survivin expression in papillary thyroid carcinoma tissues from patients in terms of gender,age,tumor diameter,TNM stage,capsule integrity and lymph node metastasis(P>0.05).There was no significant difference in the expression of MCM7 in papillary thyroid carcinoma of patients with different gender,age,and capsule integrity(P>0.05).The positive expression rate of MCM7 in papillary thyroid carcinoma tissues of patients with tumor diameter>2 cm,TNM stage III-IV,positive lymph node metastasis were higher than that of patients with tumor diameter≤2 cm,TNM stage I-II,and negative lymph node metastasis(P<0.05).Pearson correlation analysis showed that the expression of survivin and MCM7 in papillary thyroid carcinoma was significantly and positively correlated with each other(r=0.612,P<0.01).Conclusion In papillary thyroid carcinoma,the positive expression rates of survivin and MCM7 are relatively high,and are positively correlated with each other,besides,MCM7 expression is likely associated with the tumor diameter,TNM stage and lymph node metastasis in patients with papillary thyroid carcinoma,which is useful in clinical differentiation of papillary thyroid carcinoma.
作者 李伟 李永红 江晖 LI Wei;LI Yonghong;JIANG Hui(Department of Oncology,the First People’s Hospital of Tianmen City,Tianmen 431700,Hubei,China)
出处 《癌症进展》 2019年第17期2055-2058,共4页 Oncology Progress
关键词 甲状腺乳头状癌 甲状腺腺瘤 存活蛋白 微小染色体维持蛋白7 淋巴结转移 papillary thyroid carcinoma thyroid adenomal survivin minichromosome maintenance protein 7 lymph node metastasis
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