奥曲肽治疗肝硬化并发上消化道出血的临床分析

Clinical Analysis of Octreotide in the Treatment of Cirrhosis Complicated with Upper Gastrointestinal Bleeding

目的观察奥曲肽治疗肝硬化并发上消化道出血的临床效果。方法便利选择2017年9月—2018年9月期间该院收治的肝硬化上消化道出血患者84例为该次研究对象,以随机数字表法分组,对照组和研究组各42例患者,在常规治疗的基础上,对照组患者给予垂体后叶素治疗,研究组患者给予奥曲肽治疗,观察临床治疗效果。结果止血时间对比,研究组平均(20.26±0.33)h,对照组(28.34±0.74)h,差异有统计学意义(t=5.021,P=0.008),住院时间对比,研究组平均(7.19±0.69)d,对照组平均(9.72±1.03)d,差异有统计学意义(t=5.337,P=0.011)。两组患者治疗效果对比,研究组总有效38例,总有效率为90.48%;对照组总有效34例,总有效率为80.95%,研究组疗效优于对照组,差异有统计学意义(χ^2=5.777,P=0.003)。结论奥曲肽治疗肝硬化并发上消化道出血,临床疗效显著,药物安全性高,值得推广和应用。

Objective To observe the clinical effect of octreotide in the treatment of cirrhosis complicated with upper gastrointestinal bleeding.Methods From September 2017 to September 2018,84 patients with cirrhosis of upper gastrointestinal hemorrhage admitted to our hospital were convenient enrolled in this study.They were randomized to a random number table,and 42 patients in the control group and the study group each.On the basis of conventional treatment,patients in the control group were treated with vasopressin,and patients in the study group were treated with octreotide to observe the clinical treatment effect.Results The hemostasis time was compared.The study group averaged(20.26±0.33)h and the control group(28.34±0.74)h.The difference was statistically significant(t=5.021,P=0.008).The hospitalization time was compared.The study group averaged(7.19±0.69)d,the control group average(9.721±1.03)d,the difference was statistically significant(t=5.337,P=0.011).The therapeutic effect of the two groups was compared.The total effective rate was 90.48%in the study group and of 38 cases.34 cases in the control group and the total effective rate was 80.95%.The effect of the study group was better than that of the control group.The difference was statistically significant(χ^2=5.777,P=0.003).Conclusion Octreotide is effective in the treatment of cirrhosis with upper gastrointestinal hemorrhage.It has high clinical efficacy and high drug safety.It is worthy of promotion and application.