中西医结合防治恶性肿瘤化疗致消化道延迟反应的临床分析

Clinical Analysis of Integrated Traditional Chinese and Western Medicine in Preventing and Treating Delayed Response of Digestive Tract Caused by Chemotherapy

目的研究探讨使用中西医结合用于防治恶性肿瘤化疗所引起的消化道延迟反应的效果。方法便利选取2017年8月—2018年8月该院收治的恶性肿瘤患者76例为研究对象。所有患者采用相应的化疗方案,随机将其分为均等的两组。其中对照组于化疗前15min采用地塞米松10mg+托烷司琼5mg行静脉滴注,1次/d,连续治疗1周。观察组患者在此基础上联合应用中药治疗。观察两组患者的临床疗效及临床症状评分情况。结果对照组患者的总有效率为76.31%,观察组患者的总有效率为92.10%,观察组患者的总有效率显著优于对照组,差异有统计学意义(χ^2=8.219,P=0.001)。临床症状评分对比,治疗后,观察组脘腹不适评分优于对照组,差异有统计学意义(t=5.248,P=0.002);观察组食欲下降评分优于对照组,差异有统计学意义(t=6.417,P=0.016);观察组倦怠乏力评分优于对照组,差异有统计学意义(t=5.841,P=0.008);观察组口淡无味评分显著优于对照组,差异有统计学意义(t=7.429,P=0.006)。结论中西医结合用于防治恶性肿瘤化疗所引起的消化道延迟反应具有较好的临床效果,且对肠道的刺激作用较小,不良反应较少,值得临床推广使用。

Objective To investigate the effect of the combination of traditional Chinese and Western medicine on the delayed response of digestive tract caused by chemotherapy for malignant tumors.Methods 76 patients with malignant tumors admitted to our hospital from August 2017 to August 2018 were convenient selected as subjects.All patients were randomized to the same two groups using the appropriate chemotherapy regimen.The control group was intravenously infused with dexamethasone 10 mg+tropisetron 5 mg 15 minutes before chemotherapy,once a day for 1 week.Patients in the observation group were treated with Chinese medicine on this basis.The clinical efficacy and clinical symptom scores of the two groups of patients were observed.Results The total effective rate was 76.31%in the control group and 92.10%in the observation group.The total effective rate of the observation group was significantly better than that of the control group,the difference was statistically significant(χ^2=8.219,P=0.001).The clinical symptom scores were compared.After treatment,the abdominal discomfort score of the observation group was better than that of the control group.The difference was statistically significant(t=5.248,P=0.002).The appetite decline score of the observation group was superior to the control group,and the difference was statistically significant(t=6.417,P=0.016);the burnout fatigue score of the observation group was better than that of the control group,the difference was statistically significant(t=5.841,P=0.008);the score of the observation group was significantly better than that of the control group,and the difference was statistically significant(t=7.429,P=0.006).Conclusion The combination of traditional Chinese and western medicine has a good clinical effect on the prevention and treatment of delayed gastrointestinal tract caused by chemotherapy for malignant tumors.It has less stimulating effect on intestinal tract and less adverse reactions,which is worthy of clinical promotion.