诃子对肝脏保护作用的研究进展

Research progress on liver protection of Terminalia chebula

诃子是一种广泛记载于中药、蒙药和藏药经典方中的传统植物药物,成分丰富多样,主要含鞣质类、酚酸类和三萜酸类物质,可用于水煎液、提取液以及各种炮制品。诃子具有除传统的抗菌、体外抗氧化、清除自由基和抗肿瘤等功效,还具有保护肝脏的功效。诃子药理作用较多,机制复杂,现代临床研究显示,诃子是通过减毒抗氧化、降酶保肝、抑制肝癌细胞增殖及激活调节核因子红血球相关因子2(Nrf2)、AKT/Nrf2或p53等信号通路来诱导肿瘤细胞凋亡一系列方式来保护肝脏免受损伤。本文对诃子的保肝作用机制进行综述,为诃子的研发和临床应用提供参考。

Terminalia chebula is a kind of traditional plant medicine widely recorded in the classical prescriptions of traditional Chinese medicine, Mongolian medicine and Tibetan medicine. It contains tannins, phenolic acids and triterpene acids. It can be used in water decoction, extracts and various processed products. In addition to traditional antimicrobial, antioxidant, free radical scavenging and anti-cancer effects, Terminalia chebula also has the effect of protecting liver. Terminalia chebula has many pharmacological effects and complex mechanisms. Modern clinical studies have shown that Terminalia chebula can protect the liver from injury by reducing toxicity and antioxidation, reducing enzymes and protecting the liver, inhibiting the proliferation of hepatocellular carcinoma cells and activating signal pathways such as regulating nuclear factor red blood cell related factor 2 (Nrf2), AKT/Nrf2 or p53 to induce apoptosis of tumor cells. In this paper, the mechanism of liver protection of Terminalia chebula was reviewed to provide references for the research and development and clinical application of Terminalia chebula L.