原发性肝癌手术切除联合洛铂腹腔灌洗化疗的近期疗效

Short-term Efficacy of Surgical Resection of Primary Hepatocellular Carcinoma Combined with Intraperitoneal Lavage Chemotherapy with Lobaplatin

目的:研究原发性肝癌手术切除联合洛铂腹腔灌洗化疗疗效。方法:选取2016年9月-2017年9月笔者所在医院收治的原发性肝癌患者120例,随机分为对照组和研究组,各60例。对照组予以手术切除治疗,研究组在此基础上联合洛铂腹腔灌洗化疗。比较两组患者临床疗效,同时比较两组治疗前后血清甲胎蛋白(AFP)、细胞间黏附分子(sICAM-1)水平及肝脏血清酶指标。结果:治疗后,研究组临床疗效优于对照组,研究组AFP、sICAM-1水平明显低于对照组,差异均有统计学意义(P<0.05);两组治疗后AST、ALT水平差异无统计学意义(P>0.05)。结论:手术切除联合洛铂腹腔灌洗化疗方案能有效提高原发性肝癌患者的临床效果,降低腹腔种植概率,降低血中肿瘤标志物水平,延长术后患者生存期。

Objective:To study the curative effect of surgical resection of primary hepatocellular carcinoma combined with intraperitoneal lavage and chemotherapy of Lobaplatin.Method:A total of 120 patients with primary hepatocellular carcinoma admitted to our hospital from September 2016 to September 2017 were randomly divided into the control group and the research group,60 cases in each group.The control group received surgical resection,and the study group received intraperitoneal lavage chemotherapy combined with Lobaplatin.The clinical effects of the two groups were compared,and the levels of serum alpha-fetoprotein(AFP),intercellular adhesion molecule(sICAM-1) and liver serum enzymes were compared before and after treatment.Result:After treatment, the clinical efficacy of the study group was significantly higher than that of the control group(P<0.05).The levels of AFP and sICAM-1 in the study group were significantly lower than those in the control group(P<0.05).There were no significant differences in AST,ALT level between the two groups after treatment(P>0.05). Conclusion:Surgical resection combined with intraperitoneal lavage chemotherapy with Lobaplatin can effectively improve the clinical efficacy of patients with primary liver cancer,reduce the probability of intraperitoneal implantation,reduce the level of tumor markers in blood,and prolong the survival time of patients after operation.