泮托拉唑与根除幽门螺杆菌治疗对服用阿司匹林的老年患者胃及十二指肠损伤的预防价值

Preventive value of pantoprazole and Helicobacter pylori eradication on gastric and duodenal injury in elderly patients taking aspirin

目的探讨泮托拉唑与根除幽门螺杆菌(Hp)治疗对服用阿司匹林的老年患者胃及十二指肠损伤的预防价值。方法选择我院收治的服用阿司匹林的78例老年患者,采用随机数字表法将其分为单药治疗组(39例)与Hp根治组(39例)。单药治疗组给予泮托拉唑治疗,Hp根治组采用Hp根治三联治疗。比较两组患者消化道黏膜损伤评分、Hp阳性率、胃及十二指肠损伤发生率。结果治疗后,两组患者的消化道黏膜损伤评分均低于治疗前,Hp根治组低于单药治疗组(P<0.05);Hp根治组患者治疗1周后的Hp阳性率明显低于单药治疗组,胃及十二指肠症状总发生率明显低于单药治疗组(P<0.05)。结论服用阿司匹林的老年患者采用泮托拉唑与根除Hp治疗的临床效果显著,能够明显降低胃及十二指肠损伤率。

Objective To investigate the preventive value of pantoprazole and Helicobacter pylori (Hp) eradication on gastric and duodenal injury in elderly patients taking aspirin. Methods Seventy-eight elderly patients taking aspirin in our hospital were selected and divided into single drug treatment group (39 cases) and Hp radical treatment group (39 cases) by random number table method. The single drug treatment group was given pantoprazole, the Hp radical treatment group was given triple therapy of Hp eradication. The gastrointestinal mucosal injury scores, positive rates of Hp, incidences of gastric and duodenal injury were compared between the two groups. Results After treatment, the scores of gastrointestinal mucosal injury in the two groups were lower than those before treatment, and that in the Hp radical treatment group was lower than the single drug treatment group (P<0.05). The positive rate of Hp after one week of treatment in the Hp radical treatment group was significantly lower than that in the single drug treatment group, and the total incidence of gastric and duodenal injury was significantly lower than that in the single drug treatment group (P<0.05). Conclusion Pantoprazole and Hp eradication have significant clinical effect in the treatment of elderly patients taking aspirin, which can significantly reduce incidence of gastric and duodenal injury.