酪酸梭菌联合锌制剂治疗小儿腹泻的效果及对血锌、炎性因子水平的影响

Effect of Clostridium butyricum combined with zinc preparation on diarrhea in children and its influence on the levels of serum zinc and inflammatory factors

目的探究酪酸梭菌联合锌制剂治疗小儿腹泻的效果及对血锌、炎性因子水平的影响。方法选择本院收治的100例腹泻患儿作为研究对象,按照入院先后顺序将其分为对照组与观察组,每组50例。对照组患儿给予蒙脱石散治疗,观察组患儿给予酪酸梭菌联合葡萄糖酸锌口服液治疗。比较两组腹泻患儿的临床疗效、临床症状改善时间、血锌、血清炎性因子水平、不良反应发生情况及复发率。结果观察组患儿的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组患儿发热、呕吐、腹痛、常规便检改善时间均早于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患儿血锌、hsCRP、TNF-α、IL-6、IL-8、IL-10水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿血锌和IL-10水平均升高,hsCRP、TNF-α、IL-6、IL-8水平均降低,且观察组优于对照组(P<0.05)。随访6个月,观察组患儿复发率为0.00%,低于对照组患儿的8.00%,差异具有统计学意义(P<0.05)。结论酪酸梭菌联合锌制剂治疗小儿腹泻能够明显改善患儿病情,尽早消除患儿临床表现,并提高治疗效果,调节血锌水平,降低血清炎性因子水平。

Objective To explore the effect of Clostridium butyricum combined with zinc preparation in the treatment of infantile diarrhea and its influence on the levels of blood zinc and inflammatory factors. Methods A total of 100 children with diarrhea admitted in our hospital were selected as the research objects. The children were divided into control group and observation group according to the order of admission, with 50 cases in each group. The control group was given montmorillonite powder treatment, while the observation group was given Clostridium butyricum combined with zinc gluconate oral liquid. The clinical efficacy, improvement time of clinical symptoms, levels of serum zinc and serum inflammatory factors, incidence of adverse reactions and recurrence rate were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that of the control group(P <0.05). The improvement time of fever, vomiting, abdominal pain and routine stool examination in the observation group were earlier than those in the control group(P<0.05). Before treatment, there were no significant differences in the levels of serum zinc,hs-CRP, TNF-α, IL-6, IL-8 and IL-10 between the two groups(P>0.05);after treatment, the levels of serum zinc and IL-10 in the two groups increased, while the levels of serum hs-CRP, TNF-α, IL-6 and IL-8 decreased, and those of the observation group were better than the control group(P <0.05). After 6 months of follow-up, the recurrence rate of the observation group was 0.00%, which was lower than 8.00% of the control group(P<0.05). Conclusion Clostridium butyricum combined with zinc preparation in the treatment of infantile diarrhea can significantly improve the condition of children,eliminate the clinical manifestations of children as soon as possible, improve the treatment effect, regulate blood zinc level,and reduce the level of serum inflammatory factors.