放化疗同步治疗对食管癌术后的临床效果及对复发、生存情况的影响

Clinical Effect of Concurrent Radiotherapy and Chemotherapy on Postoperative Esophageal Cancer and Its Influence on Recurrence and Survival

目的:研究食管癌患者术后应用放化疗同步治疗的效果及对复发率、生存率的影响。方法:选取笔者所在医院2016年3月-2017年12月收治的72例接受食管癌手术患者,将其按照随机数字表法分为对照组与观察组,各36例。对照组实施TP方案治疗,观察组则实施TP方案联合三维适形调强放疗同步治疗。比较两组患者临床治疗效果、复发率、生存率。结果:观察组治疗总有效率为83.3%,对照组治疗总有效率为41.7%,两组比较差异有统计学意义(P<0.05)。两组患者治疗后3、6个月生存率与复发率比较,差异均无统计学意义(P>0.05)。治疗12个月后,观察组患者复发率显著低于对照组,生存率显著高于对照组,差异均有统计学意义(P<0.05)。结论:针对食管癌患者术后的治疗过程中,实施TP化疗方案联合三维适形调强放疗同步治疗,可提高患者临床疗效,降低12个月后复发率,提高生存率,值得临床大力推广应用。

Objective:To study the effect of concurrent radiotherapy and chemotherapy on recurrence rate and survival rate of patients with esophageal cancer after operation.Method:A total of 72 patients with esophageal cancer who were treated in our hospital from March 2016 to December 2017 were selected and divided into control group and observation group according to random number table method,36 cases in each group.The control group was treated with TP regimen,while the observation group was treated with TP regimen combined with three-dimensional conformal intensity modulated radiation therapy.The clinical efficacy,recurrence rate and survival rate of the two groups were compared.Result:The total effective rate of the observation group was 83.3%,and that of the control group was 41.7%,and the difference between the two groups was statistically significant(P<0.05).There was no significant difference in survival rate and recurrence rate between the two groups at 3 and 6 months after treatment(P>0.05).After 12 months of treatment,the recurrence rate in the observation group was significantly lower than that in the control group,and the survival rate was significantly higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:In the course of postoperative treatment of esophageal cancer patients,TP chemotherapy combined with three-dimensional conformal intensity modulated radiotherapy can improve the clinical efficacy of patients,reduce the recurrence rate after 12 months,and improve the survival rate,which is worthy of clinical application.