急性早幼粒细胞白血病治疗方案的优化研究

Optimized Treatment of Acute Promyelocytic Leukemia

目的研究急性早幼粒细胞白血病治疗方案的优化。方法选取我院62 例急性早幼粒细胞白血病患者,随机纳入常规组(31 例)及优化组(31 例),分别运用全反式维甲酸常规治疗方案及全反式维甲酸联合三氧化二砷的优化治疗方案,对比两组患者的临床效果。结果优化组治疗后的血小板计数与凝血功能指标均优于常规组,总有效率(93.5%)高于常规组(71.0%),不良反应发生率(9.7%)低于常规组(25.8%),差异均有统计学意义(P <0.05)。结论优化急性早幼粒细胞白血病治疗方案,可明显改善血小板功能,提高临床疗效,降低不良反应发生率,值得推行。

Objective To study the optimization of treatment regimen for acute promyelocytic leukemia. Methods 62 patients with acute promyelocytic leukemia in our hospital were randomly divided into routine group (31 cases) and optimization group (31 cases). All-trans retinoic acid routine treatment and all-trans retinoic acid combined with arsenic trioxide optimal treatment were used to compare the clinical effects of the two groups. Results After treatment, the platelet count and coagulation function in the optimization group was better than that in the conventional group, the total effective rate (93.5%) was higher than that of the routine group (71.0%), the incidence of adverse reactions (9.7%) was lower than that of the routine group (25.8%), The difference was statistically significant (P < 0.05). Conclusion Optimizing the treatment of acute promyelocytic leukemia can significantly improve platelet function, improve clinical efficacy, reduce the incidence of adverse reactions, which is worth promoting.