PCI联合替罗非班治疗急性ST段抬高型心肌梗死的临床效果

Clinical effect of PCI combined with tirofiban in the treatment of acute ST-segment elevation myocardial infarction

目的探究单纯经皮冠状动脉介入治疗(PCI)联合替罗非班治疗急性ST段抬高型心肌梗死(STEMI)的临床效果。方法回顾性分析我院心脑血管科2017年6月至2018年7月收治的120例STEMI患者的临床资料,根据治疗方式的不同将其分为观察组(60例)与对照组(60例),观察组给予PCI联合替罗非班治疗,对照组给予PCI治疗。比较两组患者手术前、后冠状动脉血流TIMI分级情况、术后心功能相关指标及术后半年内不良心血管事件发生情况。结果手术后,观察组TIMIⅢ级发生率达到100.00%,显著高于对照组的83.33%,差异具有统计学意义(P<0.05)。术后半年,观察组患者的LVEF、LVESD、LVEDD及BNP水平均优于术后1周及对照组,差异具有统计学意义(P<0.05)。观察组患者术后半年内不良心血管事件总发生率为6.67%,显著低于对照组的28.33%,差异有统计学意义(P<0.05)。结论PCI联合替罗非班在STEMI患者中的应用效果显著,能够有效改善冠状动脉血流TIMI分级,改善患者心功能,减少不良心血管事件的发生,值得推广和应用。

Objective To explore the clinical effect of percutaneous coronary intervention (PCI) combined with tirofiban in the treatment of acute ST-segment elevation myocardial infarction (STEMI). Methods The clinical data of 120 STEMI patients admitted in cardio cerebrovascular department of our hospital from June 2017 to July 2018 were retrospectively analyzed, according to the different treatment methods, the patients were divided into observation group (60 cases) and control group (60 cases). The observation group was treated with PCI combined with tirofiban, while the control group was treated with PCI. The TIMI grading of coronary blood flow before and after operation, related indexes of postoperative cardiac function and adverse cardiovascular events in six months after operation were compared between the two groups. Results After the surgery, the incidence of TIMI Ⅲ in the observation group reached 100.00%, which was significantly higher than 83.33% of the control group, the difference was statistically significant (P<0.05). Six months after operation, the LVEF, LVESD, LVEDD and levels of BNP of the observation group were better than those in one week after opertion and the control group, the differences were statistically significant (P<0.05). The total incidence of adverse cardiovascular events in six months after operationin the observation group was 6.67%, which was significantly lower than 28.33% in the control group, and the difference was statistically significant (P<0.05). Conclusion PCI combined with tirofiban has a significant effect in STEMI patients, it can effectively improve the TIMI grading of coronary blood flow and the cardiac function of patients, and reduce the occurrence of adverse cardiovascular events, which is worthy of promotion and application.