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艾司奥美拉唑或奥美拉唑为主的三联法治疗Hp阳性消化性溃疡的有效性和安全性比较 被引量:6

Comparison of effectiveness and safety of esomeprazole or omeprazole-based triple therapy in the treatment of Hp-positive peptic ulcer
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摘要 目的比较艾司奥美拉唑或奥美拉唑为主的三联疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡的有效性和安全性。方法将我院2015年1月至2018年12月收治的130例Hp阳性消化性溃疡患者按不同用药方案分为观察组与对照组,各65例。对照组采用奥美拉唑三联疗法治疗,观察组采用艾司奥美拉唑三联疗法治疗。比较两组的治疗效果。结果观察组的治疗总有效率及Hp根除率均高于对照组(P<0.05);治疗后,两组患者的IL-8、TNF-α水平均降低,CD4^+、CD8^+水平均升高,观察组均优于对照组(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论艾司奥美拉唑三联疗法治疗Hp阳性消化性溃疡的效果更显著,能有效根除Hp,改善炎症反应,提高机体免疫功能,且不增加不良反应,安全有效。 Objective To compare the effectiveness and safety of esomeprazole or omeprazole-based triple therapy admitted in the treatment of Helicobacter pylori (Hp) positive peptic ulcer. Methods A total of 130 cases of Hp-positive peptic ulcer in our hospital fromJanuary 2015 to December 2018 were divided into observation group and control group according to different medication regimens, with 65 cases in each group. The control group was treated with omeprazole-based triple therapy, while the observation group was treated with esomeprazole-based triple therapy. The treatment effects were compared between the two groups. Results The total effective rate of treatment and eradication rate of Hp in the observation group were higher than those in the control group (P<0.05). After treatment, the levels of IL-8 and TNF-α in both groups decreased, while the levels of CD4^+ and CD8^+ increased, and those in the observation group were superior to the control group (P<0.05). There was no significant difference in the total incidences of adverse reactions between the two groups (P>0.05). Conclusion Esomeprazolebased triple therapy is more effective in the treatment of Hp-positive peptic ulcer. It can effectively eradicate Hp, improve inflammation and immune function without increasing adverse reactions. It is safe and effective.
作者 段红妮 DUAN Hong-ni(the Second Hospital of Weinan, Weinan 714000, China)
机构地区 渭南市第二医院
出处 《临床医学研究与实践》 2019年第25期51-52,共2页 Clinical Research and Practice
关键词 HP阳性 消化性溃疡 艾司奥美拉唑 奥美拉唑 炎症反应 Hp-positive peptic ulcer esomeprazole omeprazole inflammatory response
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