复方丹参注射液联合甘露醇加地塞米松治疗腰椎间盘突出症的临床效果

Clinical effect of compound salvia miltiorrhiza injection combined with mannitol and dexamethasone in the treatment of lumbar intervertebral disc herniation

目的分析复方丹参注射液联合甘露醇加地塞米松治疗腰椎间盘突出症的临床效果。方法将我院2017年10月至2018年9月收治的150例腰椎间盘突出症患者按数字随机分组法分为对照组和观察组,各75例。对照组采用常规治疗,观察组在对照组的基础上采用复方丹参注射液+甘露醇+地塞米松治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组IL-1β和TNF-α水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组物质生活、躯体功能、心理功能、社会功能评分均升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论复方丹参注射液联合甘露醇加地塞米松治疗腰椎间盘突出症的临床效果显著,可降低患者的炎性因子水平,抑制各炎性因子的表达,安全性较高,是一种理想的治疗方式,值得推广。

Objective To investigate the clinical effect of compound salvia miltiorrhiza injection combined with mannitol and dexamethasone in the treatment of lumbar intervertebral disc herniation. Methods A total of 150 patients with lumbar intervertebral disc herniation admitted in our hospital from October 2017 to September 2018 were divided into control group and observation group by digital random grouping method, with 75 cases in each group. The control group was treated with routine treatment, while the observation group was treated with compound salvia miltiorrhiza injection +mannitol +dexamethasone on the basis of the control group. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the levels of IL-1β and TNF-α in both groups decreased, and those in the observation group were lower than the control group(P <0.05). After treatment, the scores of material life, physical function, psychological function and social function of the two groups increased, and those of the observation group were higher than the control group(P <0.05).Conclusion Compound salvia miltiorrhiza injection combined with mannitol and dexamethasone in the treatment of lumbar intervertebral disc herniation has a significant clinical effect. It can reduce the level of inflammatory factors, inhibit the expression of inflammatory factors and has a high safety, which is an ideal treatment method and is worth promoting.