摘要
目的探讨阿替普酶静脉溶栓联合丁苯酞治疗超早期脑梗死的临床效果。方法选取2016年1月至2019年1月我院收治的64例超早期脑梗死患者为研究对象,按照随机数表法将其分为对照组(32例,阿替普酶静脉溶栓)与观察组(32例,阿替普酶静脉溶栓+丁苯酞)。比较两组患者的治疗效果。结果观察组患者治疗总有效率高于对照组(P<0.05);治疗后3d,两组患者SOD及MDA水平均明显改善,且观察组优于对照组(P<0.05);治疗后,两组患者CRP、IL-8及IL-10的水平均低于治疗前,且观察组低于对照组(P<0.05)。结论阿替普酶静脉溶栓联合丁苯酞治疗超早期脑梗死效果显著,可以缓解患者的氧化应激损伤,减轻患者的炎症反应。
Objective To explore the clinical effect of intravenous thrombolysis with ateplase and butylphthalide in the treatment of ultra-early cerebral infarction. Methods Sixty-four patients with ultra-early cerebral infarction admitted in our hospital from January 2016 to January 2019 were selected as the research objects and divided into control group (32 cases, intravenous thrombolysis with ateplase) and observation group (32 cases, intravenous thrombolysis with ateplase+ butylphthalide) according to random number table method. The treatment effects of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group (P<0.05);at 3 d after treatment, the levels of SOD and MDA in the two groups significantly improved, and those in the observation group were better than the control group (P<0.05);after treatment, the levels of CRP, IL-8 and IL-10 in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). Conclusion Intravenous thrombolysis with ateplase and butylphthalide in the treatment of ultra -early cerebral infarction has a significant effect, which can alleviate oxidative stress injury and inflammation of patients.
作者
董贞
张玲如
DONG Zhen;ZHANG Ling-ru(the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038;Shaanxi Friendship Hospital, Xi'an 710068, China)
出处
《临床医学研究与实践》
2019年第24期25-26,共2页
Clinical Research and Practice
关键词
阿替普酶
丁苯酞
超早期脑梗死
arteplase
butylphthalide
ultra-early cerebral infarction