阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的效果

Effect of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy

目的探究阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的效果。方法选取2016年8月至2018年8月我院收治的糖尿病肾病患者68例作为研究对象,采用随机数字分组法将其分为A组与B组,每组34例。A组给予阿魏酸哌嗪联合厄贝沙坦治疗,B组单独使用厄贝沙坦治疗。比较两组的治疗效果。结果 A组治疗总有效率高于B组,不良反应总发生率低于B组(P<0.05)。治疗后,A组患者的空腹血糖、糖耐受值、餐后2 h血糖、糖化血红蛋白、甘油三酯、肌酐、尿氮素及尿酸水平均优于B组(P<0.05)。结论阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的效果较好,治疗安全性高,值得推广。

Objective To explore the effect of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy. Methods A total of 68 patients with diabetic nephropathy admitted in our hospital from August 2016 to August 2018 were selected as the research objects. The patients were divided into group A and group B by random number grouping method, with 34 cases in each group. The group A was treated with piperazine ferulate combined with irbesartan, while the group B was treated with irbesartan alone. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the group A was higher than that in the group B, and the total incidence of adverse reactions was lower than that in the group B (P<0.05). After treatment, the levels of fasting plasma glucose, glucose tolerance, 2 h postprandial blood glucose, glycated hemoglobin, triglyceride, creatinine, urea nitrogen and uric acid in the group A were better than those in the group B (P<0.05). Conclusion Piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy is effective, safe and worthy of promotion.