合理减重对采用天晴甘平治疗的转氨酶升高的非酒精性脂肪肝患者的肝脏脂肪含量及生活质量等的影响

Effects of reasonable weight loss on liver fat content and life quality in nonalcoholic fatty liver disease patients with elevated transaminase treating with diammonium glycyrrhizinate enteric-coated capsule

目的探讨减重对采用天晴甘平治疗的转氨酶升高的非酒精性脂肪肝(NAFLD)患者的肝脏脂肪含量及生活质量等的影响。方法选取2015年3月至2017年12月在广西钦州市第一人民医院采用天晴甘平治疗的转氨酶升高的NAFLD患者100例为研究对象,采用随机数字表法分为观察组与对照组,每组50例。对照组患者给予天晴甘平治疗,观察组患者给予天晴甘平治疗+合理减重干预。比较两组患者在干预前及干预6个月后的BMI、腹围、腰臀比、肝脏脂肪含量及生活质量。结果干预6个月后,两组患者的BMI、腹围、腰臀比均显著减小,观察组患者的BMI、腹围、腰臀比均显著小于对照组,差异有统计学意义(P<0.05);观察组患者的肝脏脂肪含量明显低于对照组,差异有统计学意义(P<0.05);观察组患者各领域的生活质量评分以及总评分明显高于对照组,差异有统计学意义(P<0.05)。结论对给予天晴甘平治疗的转氨酶反复升高的NAFLD患者,制定个性化饮食及运动锻炼方案并加以实施,使患者合理减重,能明显减少其肝脏脂肪含量,提高生活质量。

Objective To explore weight loss on liver fat content and life quality in nonalcoholic fatty liver disease(NAFLD) patients with elevated transaminase in the treatment of diammonium glycyrrhizinate enteric-coated capsule.Methods A total of 100 NAFLD patients with elevated transaminase,who were treated with diammonium glycyrrhizinate enteric-coated capsule,admitted in the First People′s Hospital of Qinzhou from March 2015 to December 2017 were selected as the study objects,and randomly divided into observation group and control group,with 50 cases in each group.Patients in the control group were treated with diammonium glycyrrhizinate enteric-coated capsule,whereas patients in the observation group were treated with diammonium glycyrrhizinate enteric-coated capsule and reasonable weight loss intervention.The BMI,abdominal circumference,waist-to-hip ratio,liver fat content,and life quality before and after intervention were compared between the two groups.Results After 6 months of intervention,the BMI,abdominal circumference,and waist-to-hip ratio in the two groups were significantly decreased.The BMI,abdominal circumference,and waist-to-hip ratio in the observation group were significantly less than those of the control group,with statistically significant difference ( P <0.05).Compared to the control group,the observation group had a lower liver fat content,whereas higher life quality scores in various fields and total scores of life quality,with statistically significant difference ( P <0.05).Conclusion A personalized diet and exercise scheme should be formulated and implemented on NAFLD patients with repeatedly elevated transaminase treating with diammonium glycyrrhizinate enteric-coated capsule,so as to lose the weight of patients reasonably,which can significantly reduce liver fat content and improve patients′ life quality.