卡维地洛和美托洛尔治疗高血压效果及对糖脂代谢的影响

Effect of carvedilol and metoprolol on hypertension and its effect on glucose and lipid metabolism

目的探究卡维地洛和美托洛尔治疗高血压效果及对糖脂代谢的影响。方法随机选取2017年7月至2018年8月在本院治疗高血压患者共50例,根据患者入院治疗单双号顺序分为实验组与对照组,每组例数为25例,实验组采用卡维地洛治疗,对照组采用美托洛尔治疗,分别观察两组患者血压、空腹血糖、餐后2 h血糖、总胆固醇、甘油三脂、低密度脂蛋白、高密度脂蛋白。结果治疗后实验组空腹血糖、餐后2 h血糖、总胆固醇、甘油三脂、低密度脂蛋白、高密度脂蛋白均优于对照组(5.03±0.17 vs. 6.49±0.31;9.81±1.66 vs. 11.36±1.82;4.97±0.31 vs. 6.02±0.91;1.64±0.16 vs. 1.98±0.52;3.21±0.22 vs. 3.70±0.11;1.60±0.14 vs. 1.46±0.15)mmo I/L;临床治疗总有效率高于对照组(88.00%>64.00%)(P<0.05)。结论卡维地洛改善高血压、糖脂代谢效果优于美托洛尔,具有独特的优势,值得临床广泛推广应用。

Objective To explore the effect of carvedilol and metoprolol on hypertension and its effects on glucose and lipid metabolism.Methods A total of 50 hypertensive patients were randomly selected from July 2017 to August 2018 in our hospital. According to the order of admission treatment, the patients were divided into experimental group and control group, 25 cases in each group. The experimental group was treated with carvedilol and the control group was treated with metoprolol. Blood pressure, fasting blood sugar;postprandial 2 hours blood sugar, total cholesterol, glycerin three fat, low density protein fat, high density protein fat were observed in the two groups. Results After treatment, the fasting blood glucose, postprandial 2 hour blood glucose, total cholesterol, triglyceride, low-density protein lipid and high-density protein lipid in the experimental group were better than those in the control group(5.03±0.17 vs. 6.49±0.31;9.81±1.66 vs. 11.36±1.82;4.97±0.31 vs. 6.02±0.91;1.64±0.16 vs. 1.98±0.52;3.21±0.22 vs. 3.70±0.11;1.60±0.14 vs. 1.46±0.15) mmol/L;the total effective rate of clinical treatment was higher than that of the control group(88.00%>64.00%)(P<0.05). Conclusion Carvedilol can improve hypertension and sugar-paper lipid metabolism more effectively than metoprolol. It has unique advantages and is worthy of wide clinical application.