高同型半胱氨酸血症与血清白细胞介素-6、内皮素-1及一氧化氮的相关性研究

Correlation study between the levels of serum interleukin 6, endothelin 1 and nitric oxide,and hyperhomocysteinemia

目的:研究冠心病病人血清同型半胱氨酸(HCY)与白细胞介素(IL)-6、内皮素(ET)-1、一氧化氮(NO)之间的相关性。方法:选取经冠状动脉造影确诊为冠心病的病人160例为观察组,其中合并高同型半胱氨酸血症者64例为HHCY组,同型半胱氨酸水平正常者96例为非HHCY组,另选取同期冠状动脉造影阴性者40例为对照组。测定血清IL-6、ET-1和NO水平,比较各组间差异。结果:观察组中HHCY血症发病率高于对照组(P<0.01)。HHCY组和非HHCY组之间体质量指数、吸烟、IL-6、NO、ET-1差异有统计学意义(P<0.01)。HHCY组中HCY与IL-6、ET-1呈正相关关系(P<0.01);HCY与NO呈负相关关系(P<0.01)。HHCY组中急性冠脉综合征发生率明显高于非HHCY组(P<0.01)。结论:HHCY血症与冠心病的临床严重程度相关。HHCY血症可能通过促进体内炎症反应进一步导致血管内皮功能紊乱而参与了冠心病的发病过程。

Objective:To study the correlation between the serum homocysteine(HCY),and interleukin 6(IL-6),endothelin 1(ET-1)and nitric oxide(NO)in patients with coronary heart disease(CHD).Methods:One hundred and sixty with CHD[including 64 cases with hyperhomocysteinemia(HHCY group)and 96 cases with normal homocysteine(non-HHCY group),and 40 patients with negative coronary angiography were divided into the observation group and control group,respectively.The serum levels of IL-6,ET-1 and NO in all cases were measured,and the difference of which was compared.Results:The incidence rate of HHCY in observation group was higher than that in control group(P<0.01).The differences of the BMI,smoking,IL-6,NO and ET-1 between HHCY group and non-HHCY group were statistically significantly(P<0.01).In HHCY group,HCY was positively correlated with IL-6 and ET-1(P<0.01);and HCY was negatively correlated with NO(P<0.01).The incidence rate of acute coronary syndrome in HHCY group was significantly higher than that in non-HHCY group(P<0.01).Conclusions:Hyperhomocysteinemia is related to the clinical severity of CHD.Hyperhomocysteinemia may be involved in the pathogenesis of CHD by promoting the inflammatory reaction to lead to the dysfunction of vascular endothelium.