加味化痰通络汤对风痰瘀阻型缺血性中风患者神经功能及血清炎性因子的影响

Effect of Modified Huatan Tongluo Decoction on Neurological Function and Serum Inflammatory Factor in Ischemic Stroke Patients with Wind Phlegm and Blood Stasis Syndrome

目的探讨加味化痰通络汤治疗风痰瘀阻型缺血性中风的临床疗效及对患者神经功能及血清炎性因子的影响。方法选取医院2014年3月至2017年3月收治的风痰瘀阻型缺血性中风患者94例,按入院顺序随机分为对照组和观察组,各47例。两组患者均予常规基础治疗,观察组患者加用加味化痰通络汤,两组均治疗28 d。结果观察组总有效率为89. 36%,显著高于对照组的74. 47%(P <0. 05);与治疗前比较,两组患者治疗后美国国立卫生院卒中量表(NIHSS)评分及血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及超敏C-反应蛋白(hs-CRP)水平显著下降(P <0. 05),日常生活能力评定量表(Barthel指数)评分显著升高(P <0. 05),且观察组患者上述指标改善程度均显著优于对照组(P <0. 05);观察组与对照组不良反应发生率相当(10. 64%比17. 02%,χ^2=1. 495,P=0. 308>0. 05)。结论化痰通络汤可促进风痰瘀阻型缺血性中风患者神经功能恢复,改善机体炎性状态,提高生活能力,且不增加不良反应。

Objective To investigate the clinical efficacy of modified Huatan Tongluo Decoction in the treatment of ischemic stroke patients with wind phlegm and blood stasis syndrome and its effect on neurological function and serum inflammatory factor. Methods Totally 94 ischemic stroke patients with wind phlegm and blood stasis syndrome admitted to our hospital from March 2014 to March 2017 were selected and randomly divided into the control group and the observation group according to the order of admission,47 cases in each group. The patients in the two groups were given routine basic treatment,on this basis,the patients in the observation group were treated with modified Huatan Tongluo Decoction. Both groups were treated for 28 d. Results The total effective rate of the observation group was 89. 36%,which was significantly higher than 74. 47% of the control group ( P < 0. 05 ). Compared with those before treatment,the National Institutes of Health Stroke Scale ( NIHSS ) score and levels of serum interleukin - 6 ( IL - 6 ),tumor necrosis factor -α( TNF -α) and high - sensitivity C - reactive protein ( hs - CRP ) in the two groups were significantly decreased after treatment ( P < 0. 05 ), while the scores of Barthel indexes in the two groups were significantly increased after treatment ( P < 0. 05 ),and the improvement of the above indexes in the observation group was significantly better than that in the control group ( P < 0. 05 ). The incidence of adverse reactions in the observation group was similar to that in the control group ( 10. 64% vs. 17. 02%,χ^ 2 = 1. 495,P = 0. 308 > 0. 05 ). Conclusion Modified Huatan Tongluo Decoction in treatment of ischemic stroke patients with wind phlegm and blood stasis syndrome can promote the recovery of neurological function,improve the inflammatory of the body and the activity of daily living without increas- ing adverse reactions.