超声引导经皮注射无水乙醇与聚桂醇治疗甲状腺囊性结节疗效对比

Comparison of Ultrasound-Guided Percutaneous Ethanol Injection and Percutaneous Lauromacrogol Injection in the Treatment of Cystic Thyroid Nodule

目的比较超声引导经皮注射无水乙醇(PEI)与聚桂醇(PLI)治疗甲状腺囊性结节的疗效。方法选取医院2017年1月至2018年1月收治的甲状腺囊性结节患者100例,按随机数字表法分为PEI组与PLI组,各50例,超声引导下分别行PEI治疗及PLI治疗。结果 PEI组和PLI组的总有效率与治愈率相当(92. 00%比90. 00%,88. 00%比86. 00%,P> 0. 05);与治疗前比较,两组患者治疗后1周、1个月、3个月、6个月的囊腔体积均显著减小(P <0. 05);PEI组不良反应发生率为24. 00%,显著高于PLI组的8. 00%(P <0. 05);囊液性质及囊壁和囊腔内情况是影响上述硬化疗效的主要因素(P <0. 05)。结论两种硬化剂超声引导下治疗甲状腺囊性结节的临床疗效相当,但PLI安全性较高;两种治疗方法对囊腔内情况复杂、囊壁不规则、囊液黏稠的甲状腺囊性结节疗效均较差。

Objective To compare the efficacy and safety of ultrasound - guided percutaneous ethanol injection ( PEI ) and percutaneous lauromacrogol injection ( PLI ) in the treatment of cystic thyroid nodule. Methods Totally 100 patients with cystic thyroid nodule admit- ted to our hospital from January 2017 to January 2018 were selected and divided into PEI group and PLI group according to the random number method,50 cases in each group. Under the guidance of ultrasound,PEI group was treated with PEI,while PLI group was treated with PLI. Results The total effective rate and cure rate of PEI group were similar to those of PLI group ( 92. 00% vs. 90. 00%,88. 00% vs. 86. 00%,P > 0. 05 ). Compared with those before treatment,the volume of cysts in the two groups was signifi- cantly decreased in 1 week,1 month,3 months and 6 months after treatment ( P < 0. 05 ). The incidence of adverse reactions in PEI group was 24. 00%,which was significantly higher than 8. 00% in PLI group ( P < 0. 05 ). The nature of cystic fluid,cystic wall and intracellular conditions were the main factors affecting the effect of the two kinds of sclerotherapy ( P < 0. 05 ). Conclusion The clinical efficacy of ultrasound - guided two kinds of sclerotherapy in the treatment of cystic thyroid nodule was comparable,but the safety of PLI was higher. The two treatment methods have poor effective in the treatment of cystic thyroid nodules with complex intracystic conditions, irregular cystic wall and thick cystic fluid.