摘要
锌指蛋白转录因子(Krüppel-like factors,KLFs)家族共17个成员,在肿瘤发生、发展中起促进或抑制作用,其中家族成员中KLF4、KLF5、KLF6、KLF8、KLF9、KLF10及KLF17与肝细胞癌(hepatocellular carcinoma,HCC)关系密切,显示HCC相关KLFs异常表达在HCC诊断、治疗中具有应用前景。本文综述了7种HCC相关KLFs研究新进展。
Krüppel-like factors(KLFs), a zinc finger protein transcription factor, have 17 family members that promote or inhibit tumorigenesis and development, factors such as KLF4, KLF5, KLF6, KLF8, KLF9, KLF10 and KLF17 are closely related to hepatocellular carcinoma(HCC). Clinical and basic researches show that abnormal expression of KLFs related to HCC progression has potential application in the diagnosis and treatment of HCC. This article reviewed the recent progress of 7 kinds of HCC-related to KLFs.
作者
孙建英
巫梦娜
姚敏
姚登福
SUN Jianying;WU Mengna;YAO Min;YAO Dengfu(Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001;Medical School of Nantong University, China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第9期1056-1062,共7页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金(31872738)
南通市科研项目计划(MS12017014-4)
关键词
肝细胞癌
KLFs
生物学行为
表达
Hepatocellular carcinoma
Krüppel-like factors
Biological features
Expression
