TCF7L2基因多态性与糖尿病肾病相关性研究进展

Advances in the Relationship between TCF7L2 Gene Polymorphism and Diabetic Nephropathy

糖尿病最常见的并发症是糖尿病肾病。约有20%~40%的糖尿病患者会得糖尿病肾病。糖尿病肾病是一种以持续性蛋白尿、肾小球滤过率渐进性下降、动脉血压升高、心血管疾病显著升高为特征的临床综合征。有研究表明TCF7L2基因多态性与糖尿病及糖尿病肾病进展的指标有密切的联系。该文主要阐述了TCF7L2与糖尿病肾病的关系,为糖尿病及糖尿病肾病的深入研究提供重要线索。

The most common complication of diabetes is diabetic nephropathy. About 20%-40% of people with diabetes get diabetic nephropathy. Diabetic nephropathy is a clinical syndrome characterized by persistent proteinuria,progressive decline in glomerular filtration rate,elevated arterial blood pressure,and markedly elevated cardiovascular disease. Studies have shown that the TCF7L2 gene polymorphism is closely related to the indicators of diabetes and diabetic nephropathy progression. This article mainly describes the relationship between TCF7L2 and diabetic nephropathy,and provides important clues for the in-depth study of diabetes and diabetic nephropathy.