PDGF与子痫前期相关性的研究进展

Advances in Research on the Relationship between PDGF and Preeclampsia

子痫前期是妊娠期特有的疾病,是一种多系统疾病,其特征在于高血压伴随母体或胎儿一种或多种其他器官系统损害。血小板源性生长因子(PDGF)是一种促有丝分裂剂,涉及细胞的迁徙、增殖、新血管形成及动脉粥样硬化病变的发生、发展。PDGF适度分泌释放对是否发生病理性妊娠极其关键,过度分泌可导致子痫前期胎盘血管病变。现将近年来与子痫前期有关的PDGF的研究进行总结。

Preeclampsia is a disease specific to pregnancy and is a multi-system disease characterized by hypertension accompanied by damage to one or more other organ systems of the mother or fetus.Platelet-derived growth factor(PDGF)is a mitogenic agent involved in cell migration,proliferation,neovascularization,and the development and progression of atherosclerotic lesions.Moderate secretion of PDGF is critical for the presence or absence of pathological pregnancy,and excessive secretion can lead to pre-eclamptic placental vasculopathy.The recent studies on PDGF related to preeclampsia are summarized.