CRRT治疗应用于危重急性肾损伤对患者肾功能及病死率的影响

Effect of CRRT Treatment on Renal Function and Mortality in Patients with Critical Acute Kidney Injury

目的探讨连续性肾脏替代治疗(CRRT)应用于危重急性肾损伤对患者肾功能及病死率的影响。方法回顾性分析2016年1月~2018年12月我院102例危重急性肾损伤患者的临床资料,根据患者所采取的治疗方式分成观察组60例和对照组42例。观察组采取原发病对症治疗及CRRT治疗,对照组接受原发病对症治疗。比较两组患者治疗1周后肾功能指标[血肌酐(Scr)、尿素氮(BUN)]变化及住院病死率。结果治疗1周后,两组Scr、BUN水平均较治疗前降低,观察组Scr和BUN分别为(173.35±43.18)μmol/L和(13.12±4.06)mmol/L,低于对照组的(221.73±60.56)μmol/L和(16.71±4.17)mmol/L,差异具有统计学意义(P<0.05);观察组患者28d住院病死率低于对照组(31.67%vs57.14%),差异具有统计学意义(P<0.05)。结论CRRT治疗可以更有效地改善急性肾损伤患者的肾功能,并显著降低患者住院病死率。

Objective To investigate the effect of continuous renal replacement therapy(CRRT)on the renal function and mortality of patients with critical acute kidney injury.Methods The clinical data of 102 patients with critically acute renal injury in our hospital from January 2016 to December 2018 were retrospectively analyzed.According to the treatment methods,60 patients in the observation group and 42 patients in the control group were divided.The observation group was treated with symptomatic treatment of primary disease and CRRT,and the control group received symptomatic treatment of primary disease.The renal function indexes[severe serum creatinine(Scr),urea nitrogen(BUN)]and hospital mortality were compared between the two groups after 1 week of treatment.Results After 1 week of treatment,the Scr and BUN levels in the two groups were lower than those before treatment.The Scr and BUN in the observation group were(173.35±43.18)μmol/L and(13.12±4.06)mmol/L,respectively,which was lower than that of the control group(221.73±60.56)μmol/L and(16.71±4.17)mmol/L,the difference was statistically significant(P<0.05).The hospital mortality rate of the observation group was lower than that of the control group at 28 d(31.67%vs 57.14%),the difference was statistically significant(P<0.05).Conclusion CRRT can more effectively improve renal function in patients with acute kidney injury and significantly reduce hospital mortality.