儿童多重耐药肺炎克雷伯杆菌脓毒症感染的研究

Study on Septic Infection of Klebsiella Pneumoniae in Children with Multi-drug Resistance

目的研究儿童多重耐药肺炎克雷伯杆菌(MDR-KP)脓毒症感染的危险因素和有效治疗方法。方法选取2016年1月~2019年1月在我院治疗的50例MDR-KP脓毒症感染患儿为研究对象,将其设为为观察组。选取同期在我院诊治的50例非MDR-KP脓毒症感染患儿设为对照组,比较两组患儿感染前使用抗生素情况、治疗效果、预后、住院时间、机械通气时间,采用多元Logistic回归分析MDR-KP脓毒症感染的危险因素。结果观察组患儿感染前使用抗生素的种类、感染前使用三代头孢和碳青霉素类抗生素均高于对照组,机械通气时间、住院时间均长于对照组,差异有统计学意义(P<0.05);对照组患儿治疗总有效率为98.00%,高于观察组的82.00%,差异有统计学意义(P<0.05);Logistic回归分析显示,感染前使用抗生素的种类、感染前使用三代头孢和碳青霉素类抗生素是MDR-KP脓毒症感染的独立危险因素(P<0.05)。结论临床依据实际病情合理选择抗生素治疗,可有效预防和降低MDR-KP感染发生。

Objective To study the risk factors and effective treatment of sepsis infection in children with multidrug-resistant Klebsiella pneumoniae(MDR-KP).Methods A total of 50 children with MDR-KP sepsis infection who were treated in our hospital from January 2016 to January 2019 were enrolled as the observation group.50 children with non-MDR-KP sepsis infection were selected as the control group in the same period.The antibiotics,treatment effect,prognosis,hospitalization time and mechanical ventilation time were compared between the two groups.Multivariate Logistic was used.Regression analysis of risk factors for MDRKP sepsis infection.Results The types of antibiotics used in the observation group before infection,the use of third-generation cephalosporins and carbomycinmycin before infection were higher than the control group,and the mechanical ventilation time and hospitalization time were longer than the control,the difference was statistically significant(P<0.05).The total effective rate was 98.00%in the control group,which was higher than 82.00%in the observation group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that the infection was infected.The type of antibiotic used before,the use of third-generation cephalosporin and carbomycin-resistant antibiotics before infection were independent risk factors for MDR-KP sepsis infection(P<0.05).Conclusion The rational selection of antibiotics based on actual conditions can effectively prevent and reduce the occurrence of MDR-KP infection.