玉泽精华乳治疗面部糖皮质激素依赖性皮炎的疗效

Effect on YuZe Essence Milk in the Treatment of Facial Corticosteroid Addictive Dermatitis

目的观察他克莫司联合玉泽皮肤屏障修护精华乳(以下简称玉泽精华乳)治疗面部糖皮质激素依赖性皮炎(以下简称激素依赖性皮炎)的临床疗效。方法选取2017年8月~2018年8月我院收治的激素依赖性皮炎患者55例作为研究对象,随机分为对照组(28例)和治疗组(27例)。对照组采用他克莫司软膏治疗,治疗组在此基础上联合玉泽精华乳治疗,于治疗2、4周后随访评估皮损症状积分、临床疗效及不良反应。结果治疗2周后,两组皮损症状总积分比较,差异无统计学意义(P>0.05);治疗4周后,治疗组皮损症状总积分低于对照组,差异有统计学意义(P<0.05);治疗2周后,对照组和治疗组总有效率分别为50.00%、62.96%,差异无统计学意义(P>0.05);治疗4周后,对照组和治疗组总有效率分别为60.71%、85.19%,差异有统计学意义(P<0.05);治疗过程中,对照组7例、治疗组3例患者出现局部潮红、烧灼及瘙痒等刺激症状,给予生理盐水湿敷后,症状逐渐消失,继续外用未出现类似不良反应。结论他克莫司软膏联合玉泽精华乳治疗面部激素依赖性皮炎的临床疗效较好,不良反应少。

Objective To observe the clinical efficacy of tacrolimus combined with Yuze skin barrier repair serum(hereinafter referred to as Yuze essence milk)in the treatment of facial glucocorticoid-dependent dermatitis(hereinafter referred to as hormone-dependent dermatitis).Methods A total of 55 patients with hormone-dependent dermatitis admitted to our hospital from August 2017 to August 2018 were enrolled in the study.They were randomly divided into the control group(28 cases)and the treatment group(27 cases).The control group was treated with tacrolimus ointment.The treatment group was treated with Yuze Essence Milk on the basis of this.The lesion scores,clinical efficacy and adverse reactions were evaluated after 2 and 4 weeks of treatment.Results After 2 weeks of treatment,there was no significant difference in the total scores of skin lesions between the two groups(P>0.05).After 4 weeks of treatment,the total score of skin lesions in the treatment group was lower than that in the control group,the difference was statistically significant(P<0.05);After 2 weeks of treatment,the total effective rate of the control group and the treatment group were 50.00%and 62.96%,respectively,the difference was not statistically significant(P>0.05).After 4 weeks of treatment,the total effective rate of the control group and the treatment group were respectively 60.71%,85.19%,the difference was statistically significant(P<0.05).During the treatment,7 cases in the control group and 3 patients in the treatment group showed localized flushing,burning and itching and other irritation symptoms.Gradually disappeared,and no similar adverse reactions occurred after continuing external use.Conclusion The efficacy of tacrolimus ointment combined with Yuze Essence in the treatment of facial hormone-dependent dermatitis is better and less adverse reactions.